PPARs as Nuclear Receptors for Nutrient and Energy Metabolism

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

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Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

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Gemfibrozil for the Secondary Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol

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Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

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Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus

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The mechanisms of action of PPARs

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mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint

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Adipocytes as regulators of energy balance and glucose homeostasis

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PPARγ signaling and metabolism: the good, the bad and the future

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Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

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Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

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PPARs and the complex journey to obesity

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Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

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C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint

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Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

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Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

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Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment.

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Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

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Secondary Prevention by Raising HDL Cholesterol and Reducing Triglycerides in Patients With Coronary Artery Disease: The Bezafibrate Infarction Prevention (BIP) Study

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Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

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PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.

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A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

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A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.

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Molecular Actions of PPARα in Lipid Metabolism and Inflammation

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The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

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Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

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Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

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High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

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Integration of metabolism and inflammation by lipid-activated nuclear receptors

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Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., ROSENBAUM, M. S., Zhao, Y., Gu, W. J., Farmer, S. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.027 · Cited by 802 · see citing works

From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

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PPARs in Obesity-Induced T2DM, Dyslipidaemia and NAFLD

Gross, B., Pawlak, M., Lefebvre, P., & Staels, B. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.135 · Cited by 778 · see citing works

The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

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Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

Montagner, A., Polizzi, A., Fouché, E., Ducheix, S., Lippi, Y., Lasserre, F., Barquissau, V., Régnier, M., Lukowicz, C., Benhamed, F., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310798 · Cited by 746 · see citing works

Reprogramming of the Circadian Clock by Nutritional Challenge

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PPARγ and the global map of adipogenesis and beyond

Lefterova, M. I., Haakonsson, A. K., Lazar, M. A., & Mandrup, S. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.04.001 · Cited by 629 · see citing works

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

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Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone

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NATURE OF THE HEPATOMEGALIC EFFECT PRODUCED BY ETHYL-CHLOROPHENOXY-ISOBUTYRATE IN THE RAT

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PPARs and molecular mechanisms of transrepression

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Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals With Type 2 Diabetes and Various Components of the Metabolic Syndrome

Scott, R., O'Brien, R., Fulcher, G., Pardy, C., d'Emden, M., Tse, D., Taskinen, M.-R., Ehnholm, C., Keech, A., & on behalf of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study Investigators (2009) · Diabetes Care · doi:10.2337/dc08-1543 · Cited by 551 · see citing works

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging

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cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

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PPARδ regulates glucose metabolism and insulin sensitivity

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Central Role of Pparα–Dependent Hepatic Lipid Turnover in Dietary Steatohepatitis in Mice

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Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids

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Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients

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Angiographic Assessment of Effects of Bezafibrate on Progression of Coronary Artery Disease in Young Male Postinfarction Patients

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Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: Hepatology

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Peroxisome Proliferator-activated Receptor α-Isoform Deficiency Leads to Progressive Dyslipidemia with Sexually Dimorphic Obesity and Steatosis

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Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.

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Thiazolidinediones and PPARγ agonists: time for a reassessment

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Role for PPARγ in obesity‐induced hepatic steatosis as determined by hepatocyte‐ and macrophage‐specific conditional knockouts

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Distinct but complementary contributions of PPAR isotypes to energy homeostasis

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Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

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The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells

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PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

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PPARs: diverse regulators in energy metabolism and metabolic diseases

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Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate

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Oxidized Low Density Lipoprotein Inhibits Interleukin-12 Production in Lipopolysaccharide-activated Mouse Macrophages via Direct Interactions between Peroxisome Proliferator-activated Receptor-γ and Nuclear Factor-κB

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Activation of Peroxisome Proliferator–Activated Receptor (PPAR)δ Promotes Reversal of Multiple Metabolic Abnormalities, Reduces Oxidative Stress, and Increases Fatty Acid Oxidation in Moderately Obese Men

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Activation of PPARδ alters lipid metabolism in db/db mice

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An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

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Up-Regulation of Peroxisome Proliferator-Activated Receptors (PPAR-α) and PPAR-γ Messenger Ribonucleic Acid Expression in the Liver in Murine Obesity: Troglitazone Induces Expression of PPAR-γ-Responsive Adipose Tissue-Specific Genes in the Liver of Obese Diabetic Mice**This work was supported by grants from the Research Service of the Department of Veterans Affairs (to C.G. and K.R.F.), NIH Grant DK-49448 (to C.G.), and Merck Research Laboratories (to L.H.T. and K.N.).

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Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

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Melatonin prevents obesity through modulation of gut microbiota in mice

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Activation of nuclear hormone receptor peroxisome proliferator–activated receptor-δ accelerates intestinal adenoma growth

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A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

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Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

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High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine

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PPARs and ERRs: molecular mediators of mitochondrial metabolism

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Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice

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Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice.

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Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons

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PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance

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A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis.

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Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans

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PFOS Inhibited Normal Functional Development of Placenta Cells via PPARγ Signaling

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The Rosmarinus Bioactive Compound Carnosic Acid Is a Novel PPAR Antagonist That Inhibits the Browning of White Adipocytes

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