Nanoscopy in a living mouse brain
Open accessAbstract
We demonstrated superresolution optical microscopy in a living higher animal. Stimulated emission depletion (STED) fluorescence nanoscopy reveals neurons in the cerebral cortex of a mouse with <70-nanometer resolution. Dendritic spines and their subtle changes can be observed at their relevant scales over extended periods of time.
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STED microscopy has also been established in vivo in mouse brain.
“Recently, STED microscopy has also been established in vivo in mouse brain (Berning et al., 2012).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Berning et al., 2012
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References 7 · Cited by 363
- Authors
- Berning, S., Willig, K. I., Steffens, H., Dibaj, P., & Hell, S. W.
- Affiliations
- Max Planck Institute for Biophysical Chemistry (DE)
- Max Planck Institute of Experimental Medicine (DE)
- Corresponding author
- Willig, Katrin I.
- Hell, Stefan W.
- Venue
- Science
- Published
- 2012-02-03
- Volume
- 335
- Issue
- 6068
- Pages
- 551-551
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2099714571
- Cited by
- 363
- References
- 7
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 10 · 2023: 21 · 2022: 21 · 2021: 27 · 2020: 19 · 2019: 21 · 2018: 28 · 2017: 30 · 2016: 31 · 2015: 38 · 2014: 44 · 2013: 41 · 2012: 22
- FWCI
- 21.19
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- GRO (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Laser-Matter Interactions and Applications
- Keywords
- STED microscopy, live imaging, mouse brain, cerebral cortex, neurons, dendritic spines, dendritic spine dynamics, in vivo imaging
- MeSH terms
- Animals, Fluorescence, Luminescent Proteins, Microscopy, Fluorescence, Somatosensory Cortex, Nanotechnology, Dendritic Spines, Mice
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