The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Crystal Structure of a Lipid G Protein–Coupled Receptor
Open accessAbstract
A Lipid-Sensing GPCR: Sphingosine 1-phosphate (S1P) is a sphingolipid that binds to the G protein–coupled receptor subtype 1 (S1P 1 ) to activate signaling pathways involved in regulation of the vascular and immune systems. Hanson et al. (p. 851 ) determined the crystal structure of S1PR in complex with an antagonist sphingolipid mimic. Ligand access to the receptor from the extracellular milieu is occluded, and a gap between helices I and VII may provide ligand access from within the membrane. The structural information, together with mutagenesis and structure activity relationship data, provides insight into the molecular recognition events that modulate signaling.
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Cites
Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E., et al. (2000) · Science · doi:10.1126/science.289.5480.739 · Cited by 5,637
Crystal structure of the β2 adrenergic receptor–Gs protein complex
Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., et al. (2011) · Nature · doi:10.1038/nature10361 · Cited by 3,009
Sanna, M. G., Wang, S.-K., Gonzalez-Cabrera, P. J., Don, A., Marsolais, D., Matheu, M. P., Wei, S. H., Parker, I., Jo, E., Cheng, W.-C., et al. (2006) · Nature Chemical Biology · doi:10.1038/nchembio804 · Cited by 406
Self-citationSphingosine 1-Phosphate Receptor Signaling
Rosen, H., Gonzalez-Cabrera, P. J., Sanna, M. G., & Brown, S. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.072407.103733 · Cited by 404
Self-citationLigand Channeling within a G-protein-coupled Receptor
Schädel, S. A., Heck, M., Maretzki, D., Filipek, S., Teller, D. C., Palczewski, K., & Hofmann, K. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302115200 · Cited by 111
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Metadata
- Authors
- Hanson, M. A., Roth, C. B., Jo, E., Griffith, M. T., Scott, F. L., Reinhart, G., Desale, H., Clemons, B., Cahalan, S. M., Schuerer, S. C., Sanna, M. G., Han, G. W., Kuhn, P., Rosen, H., & Stevens, R. C.
- Venue
- Science
- Published
- 2012-02-17
- Volume
- 335
- Issue
- 6070
- Pages
- 851-855
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2117003397
- Cited by
- 666
- References
- 5
- FWCI
- 37.06
- Type
- journal article
- Language
- en
- Open access
- green
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