The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Mechanism of Voltage Gating in Potassium Channels
Abstract
Open and Shut Case: Voltage-sensing domains (VSDs) control the activity of voltage-gated ion channels to regulate the ion flow that underlies nerve conduction. Structural and biophysical studies have provided insight into voltage gating; however, understanding has been hindered by the lack of a crystal structure of a fully closed state. Starting from a structure of an open conducting state, a voltage-gated K + channel, Jensen et al. (p. 229 ) used all-atom molecular dynamics simulations to show the conformational changes involved in switching to the closed, nonconducting state. Additional simulations revealed the major steps of channel activation. The computational determination of a closed state may guide development of drugs to treat channelopathies associated with this resting state.
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Cites
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Mechanism of NMDA receptor channel block by MK-801 and memantine
Song, X., Jensen, M. Ø., Jogini, V., Stein, R. A., Lee, C.-H., Mchaourab, H. S., Shaw, D. E., & Gouaux, E. (2018) · Nature · doi:10.1038/s41586-018-0039-9 · Cited by 264
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Metadata
- Authors
- Jensen, M. Ø., Jogini, V., Borhani, D. W., Leffler, A. E., Dror, R. O., & Shaw, D. E.
- Venue
- Science
- Published
- 2012-04-13
- Volume
- 336
- Issue
- 6078
- Pages
- 229-233
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077082977
- Cited by
- 606
- References
- 56
- FWCI
- 26.25
- Type
- journal article
- Language
- en
- Open access
- closed
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