The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Interleukin-22 Drives Endogenous Thymic Regeneration in Mice
Open accessAbstract
IL-22 Protects the Thymus: One of the side effects associated with radiation treatment and some types of chemotherapy is damage to the thymus. Immunological T cells develop in the thymus, and so damage to this organ results in immunodeficiency and increased susceptibility to infectious disease. Although the organ eventually recovers, therapies that speed this recovery process are of interest. Dudakov et al. (p. 91 , published online 1 March; see the Perspective by Bhandoola and Artis ) now show in mice that interleukin-22 (IL-22) production in the thymus is increased in response to radiation damage and that this cytokine promotes thymic repair. After radiation treatment, IL-23 production by thymic dendritic cells induced IL-22 secretion by a population of radio-resistant innate lymphoid cells. IL-22 appeared to mediate its effects by promoting the survival and proliferation of thymic epithelial cells.
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Cites
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
Pickert, G., Neufert, C., Leppkes, M., Zheng, Y., Wittkopf, N., Warntjen, M., Lehr, H.-A., Hirth, S., Weigmann, B., Wirtz, S., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082683 · Cited by 1,043
Zoned Out: Functional Mapping of Stromal Signaling Microenvironments in the Thymus
Petrie, H. T., & Zúñiga-Pflücker, J. C. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115715 · Cited by 454
Cited by
Innate lymphoid cells: A new paradigm in immunology
Eberl, G., Colonna, M., Di Santo, J. P., & McKenzie, A. N. J. (2015) · Science · doi:10.1126/science.aaa6566 · Cited by 878
Mittelbrunn, M., & Kroemer, G. (2021) · Nature Immunology · doi:10.1038/s41590-021-00927-z · Cited by 702
The Effect of Age on Thymic Function
Palmer, D. B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00316 · Cited by 494
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
Sonnenberg, G. F., & Artis, D. (2015) · Nature Medicine · doi:10.1038/nm.3892 · Cited by 503
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
Thomas, R., Wang, W., & Su, D.-M. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-0173-8 · Cited by 442
Metadata
- Authors
- Dudakov, J. A., Hanash, A. M., Jenq, R. R., Young, L. F., Ghosh, A., Singer, N. V., West, M. L., Smith, O. M., Holland, A. M., Tsai, J. J., Boyd, R. L., & van den Brink, M. R. M.
- Venue
- Science
- Published
- 2012-04-06
- Volume
- 336
- Issue
- 6077
- Pages
- 91-95
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981098031
- Cited by
- 390
- References
- 2
- FWCI
- 13.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Dudakov, J. A., Hanash, A. M., Jenq, R. R., Young, L. F., Ghosh, A., Singer, N. V., West, M. L., Smith, O. M., Holland, A. M., Tsai, J. J., Boyd, R. L., & van den Brink, M. R. M. (2012). Interleukin-22 Drives Endogenous Thymic Regeneration in Mice. Science. https://doi.org/10.1126/science.1218004
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