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Cited by 878IL-33, ST2, and ILC PathwaysT-cell and B-cell ImmunologyMast cells and histamine

Innate lymphoid cells: A new paradigm in immunology

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Eberl, Gérard, Colonna, Marco, Di Santo, James P., McKenzie, Andrew N. J.·2015·Science
DOI 10.1126/science.aaa6566PMC PMC5658207
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Abstract

Cells acting at the intersection of immunity: For years, scientists divided the immune system into two arms: innate and adaptive. The cell types involved in the two arms differ in specificity and in how quickly they respond to infections. More recently, immunologists discovered a family of immune cells termed “innate lymphoid cells,” which straddle these two arms. Eberl et al. review current understanding of innate lymphoid cells. Like innate immune cells, they respond to infection quickly and do not express antigen receptors; however, they secrete a similar suite of inflammatory mediators as T lymphocytes. Better understanding of the processes regulating these cells may allow for their therapeutic manipulation. Science , this issue 10.1126/science.aaa6566

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  • Recent studies have shown that AHR influences the maintenance of certain resident immune cells, such as innate lymphoid cells in the gut, while also aiding in the orchestration of immune responses such as cytokine production.

    “Recent studies have expanded upon these early characterizations to show that AHR influences the maintenance of certain resident immune cells, such as innate lymphoid cells in the gut, while also aiding in the orchestration of immune responses such as cytokine production (Cella & Colonna, 2015; Eberl et al., 2015; M. Kim & Kim, 2016; Zhou, 2016).”

    From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Eberl et al., 2015

    The section “How diet and the microbiota influence ILC development and activity” states that food-derived Ahr ligands are required to maintain ILC3s after birth, supporting the gut-ILC maintenance claim. “ILCs translate signal cytokines into effector cytokines” describes cytokine production by ILCs, but does not say that AHR aids or regulates that production. (LLM, conf=0.86)

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Authors
Eberl, G., Colonna, M., Di Santo, J. P., & McKenzie, A. N. J.
Affiliations
  • Institut Pasteur (FR)
  • Washington University in St. Louis (US)
  • Institut Pasteur, Innate Immunity Unit, INSERM U668, 75724 Paris, France.
  • MRC Laboratory of Molecular Biology (GB)
Corresponding author
Eberl, Gérard
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2015-05-22
Volume
348
Issue
6237
Pages
aaa6566-aaa6566
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.aaa6566
PMC
PMC5658207
OpenAlex
W1608909099
Cited by
878
References
11
Citations by year
2026: 32 · 2025: 65 · 2024: 67 · 2023: 76 · 2022: 93 · 2021: 78 · 2020: 87 · 2019: 102 · 2018: 87 · 2017: 84 · 2016: 74 · 2015: 29 · 2014: 1
FWCI
8.59
Type
journal article
Language
en
Open access
Licence
www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion, cc-by-nc-nd)
Funders
  • U.S. National Institutes of Health (1U01AI095542, R01DE021255, R21CA16719)
  • Wellcome Trust
  • UK Medical Research Council
  • Agence Nationale de la Recherche
  • ANR
  • Inserm
  • Institut Pasteur
  • Pasteur-Weizmann Council
  • La Ligue National Contre le Cancer
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Keywords
innate lymphoid cells, cytokines, innate immunity, adaptive immunity, tissue damage, immune regulation, microenvironment, immunomodulation
MeSH terms
Adipose Tissue, Bone Marrow, Diet, Biological Evolution, Humans, Immunity, Innate, Immunotherapy, Inflammation, Liver, Lymphocyte Activation, Lymphocytes, T-Lymphocytes, Cytokines, Adaptive Immunity, Microbiota

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