The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets
Open accessAbstract
Netting the Bad Guys: Antimicrobial peptides are an evolutionarily conserved component of innate immunity in the intestine. One family, α-defensins, typically exert their antimicrobial effects through microbicidal activity against bacteria. Humans express only two α-defensins, human defensin 5 (HD5) and HD6. HD5 exhibits bactericidal activity and plays a role in shaping the bacterial composition of the gut. HD6, on the other hand, does not show bactericidal activity and its function in the gut is unclear. Now, Chu et al. (p. 477 , published online 21 June; see the Perspective by Ouellette and Selsted ) show that HD6 protects against bacterial pathogens. Rather than killing them directly, HD6 binds to bacteria surface proteins and, through a process of self-assembly, forms fibrils and nanonets that ensnare invading bacterial pathogens.
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Cites
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Self-citationEnteric defensins are essential regulators of intestinal microbial ecology
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Cited by
Microbiota-mediated colonization resistance against intestinal pathogens
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Metadata
- Authors
- Chu, H., Pazgier, M., Jung, G., Nuccio, S.-P., Castillo, P. A., de Jong, M. F., Winter, M. G., Winter, S. E., Wehkamp, J., Shen, B., Salzman, N. H., Underwood, M. A., Tsolis, R. M., Young, G. M., Lu, W., Lehrer, R. I., Bäumler, A. J., & Bevins, C. L.
- Venue
- Science
- Published
- 2012-07-27
- Volume
- 337
- Issue
- 6093
- Pages
- 477-481
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2078583903
- Cited by
- 419
- References
- 31
- FWCI
- 26.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Chu, H., Pazgier, M., Jung, G., Nuccio, S.-P., Castillo, P. A., de Jong, M. F., Winter, M. G., Winter, S. E., Wehkamp, J., Shen, B., Salzman, N. H., Underwood, M. A., Tsolis, R. M., Young, G. M., Lu, W., Lehrer, R. I., Bäumler, A. J., & Bevins, C. L. (2012). Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets. Science. https://doi.org/10.1126/science.1218831
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
