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Germ Cell Migration Across Sertoli Cell Tight Junctions
Open accessAbstract
Observing Sperm Factories: The blood-testis barrier creates a permissive microenvironment for germ cell differentiation and protects meiotic germ cells from autoimmunity. To become sperm, large cysts of germline progenitors must cross the blood-testis barrier without causing damage. Smith and Braun (p. 798 , published online 20 September) show that somatic Sertoli cells, the gate-keepers of the blood-testis barrier, manage this task by building a network of compartments bounded by old and new tight junctions. Intercellular bridges, which connect germ cells within cysts, span the transient compartments by passing through vertical strands at tricellular junctions. Only after the formation of a new blood-testis barrier are old tight junctions removed and germ cells released.
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Cited by
The Sertoli cell: one hundred fifty years of beauty and plasticity
França, L. R., Hess, R. A., Dufour, J. M., Hofmann, M. C., & Griswold, M. D. (2016) · Andrology · doi:10.1111/andr.12165 · Cited by 419
The Gut Microbiota and Developmental Programming of the Testis in Mice
Al-Asmakh, M., Stukenborg, J.-B., Reda, A., Anuar, F., Strand, M.-L., Hedin, L., Pettersson, S., & Söder, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103809 · Cited by 173
“During spermatogenesis, the BTB undergoes cyclic restructuring with preleptotene spermatocytes migrating into the adluminal compartment and entering meiosis [2,3].”
Background
Metadata
- Authors
- Smith, B. E., & Braun, R. E.
- Venue
- Science
- Published
- 2012-11-09
- Volume
- 338
- Issue
- 6108
- Pages
- 798-802
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971075295
- Cited by
- 196
- References
- 0
- FWCI
- 16.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, B. E., & Braun, R. E. (2012). Germ Cell Migration Across Sertoli Cell Tight Junctions. Science. https://doi.org/10.1126/science.1219969
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
