The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine
Abstract
Alkaloid Synthetic Pathway: Noscapine, a nonaddictive alkaloid found in the opium poppy, can be used as a cough suppressant and a tubulin-binding antitumor agent. Winzer et al. (p. 1704 , published online 31 May; see the Perspective by DellaPenna and O'Connor ) found that a cluster of 10 genes were key to the production of noscapine. Poppies homozygous for this gene cluster produced high levels of noscapine, heterozygous poppies produced low levels of noscapine, and those poppies lacking the gene cluster produced no noscapine. Silencing individual genes in turn and analyzing the accumulation of intermediate metabolites allowed the biosynthetic pathway of noscapine to be elucidated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
CAP3: A DNA Sequence Assembly Program
Huang, X., & Madan, A. (1999) · Genome Research · doi:10.1101/gr.9.9.868 · Cited by 5,261
Cited by
Triterpene Biosynthesis in Plants
Thimmappa, R., Geisler, K., Louveau, T., O'Maille, P., & Osbourn, A. (2014) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120229 · Cited by 803
Synthetic biology strategies for microbial biosynthesis of plant natural products
Cravens, A., Payne, J., & Smolke, C. D. (2019) · Nature Communications · doi:10.1038/s41467-019-09848-w · Cited by 438
The opium poppy genome and morphinan production
Guo, L., Winzer, T., Yang, X., Li, Y., Ning, Z., He, Z., Teodor, R., Lu, Y., Bowser, T. A., Graham, I. A., et al. (2018) · Science · doi:10.1126/science.aat4096 · Cited by 341
Self-citationBenzylisoquinoline alkaloid biosynthesis in opium poppy
Beaudoin, G. A. W., & Facchini, P. J. (2014) · Planta · doi:10.1007/s00425-014-2056-8 · Cited by 276
Gene clustering in plant specialized metabolism
Nützmann, H.-W., & Osbourn, A. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.10.009 · Cited by 255
Metadata
- Authors
- Winzer, T., Gazda, V., He, Z., Kaminski, F., Kern, M., Larson, T. R., Li, Y., Meade, F., Teodor, R., Vaistij, F. E., Walker, C., Bowser, T. A., & Graham, I. A.
- Venue
- Science
- Published
- 2012-06-29
- Volume
- 336
- Issue
- 6089
- Pages
- 1704-1708
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067279194
- Cited by
- 337
- References
- 2
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine. https://app.cochat.ai/papers/10.1126/science.1220757
- The paper
- Winzer, T., Gazda, V., He, Z., Kaminski, F., Kern, M., Larson, T. R., Li, Y., Meade, F., Teodor, R., Vaistij, F. E., Walker, C., Bowser, T. A., & Graham, I. A. (2012). A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine. Science. https://doi.org/10.1126/science.1220757
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
