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The lac Repressor Displays Facilitated Diffusion in Living Cells
Abstract
Slide and Find: Transcription factors rapidly find their specific binding sites on chromosomal DNA. It has been proposed that searching is facilitated by complementing three-dimensional diffusion with one-dimensional diffusion along DNA. Such sliding on DNA has been observed in vitro, but whether and how far transcription factors slide along chromosomes in vivo is unclear. Hammar et al. (p. 1595 ) used single-molecule imaging to demonstrate that the lac repressor slides into its chromosomal operators in living cells. The average sliding distance was about 45 base pairs, and the repressor frequently slid over its operator before binding.
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Cited by
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Shlyueva, D., Stampfel, G., & Stark, A. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3682 · Cited by 1,356
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
Chen, J., Zhang, Z., Li, L., Chen, B.-C., Revyakin, A., Hajj, B., Legant, W., Dahan, M., Lionnet, T., Betzig, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.062 · Cited by 602
Formaldehyde Crosslinking: A Tool for the Study of Chromatin Complexes
Hoffman, E. A., Frey, B. L., Smith, L. M., & Auble, D. T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.651679 · Cited by 441
Biological processes as exploratory dynamics
Kondev, J., Kirschner, M., Garcia, H. G., Salmon, G. L., & Phillips, R. (2026) · Biophysical Journal · doi:10.1016/j.bpj.2025.09.009 · Cited by 4
Metadata
- Authors
- Hammar, P., Leroy, P., Mahmutovic, A., Marklund, E. G., Berg, O. G., & Elf, J.
- Venue
- Science
- Published
- 2012-06-22
- Volume
- 336
- Issue
- 6088
- Pages
- 1595-1598
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993051221
- Cited by
- 408
- References
- 0
- FWCI
- 18.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hammar, P., Leroy, P., Mahmutovic, A., Marklund, E. G., Berg, O. G., & Elf, J. (2012). The lac Repressor Displays Facilitated Diffusion in Living Cells. Science. https://doi.org/10.1126/science.1221648
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