The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Formaldehyde Crosslinking: A Tool for the Study of Chromatin Complexes
Open accessAbstract
Formaldehyde has been used for decades to probe macromolecular structure and function and to trap complexes, cells, and tissues for further analysis. Formaldehyde crosslinking is routinely employed for detection and quantification of protein-DNA interactions, interactions between chromatin proteins, and interactions between distal segments of the chromatin fiber. Despite widespread use and a rich biochemical literature, important aspects of formaldehyde behavior in cells have not been well described. Here, we highlight features of formaldehyde chemistry relevant to its use in analyses of chromatin complexes, focusing on how its properties may influence studies of chromatin structure and function.
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Cites
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Unbiased spatial proteomics with single-cell resolution in tissues
Mund, A., Brunner, A.-D., & Mann, M. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.05.022 · Cited by 259
Genome-wide spatial expression profiling in formalin-fixed tissues
Gracia Villacampa, E., Larsson, L., Mirzazadeh, R., Kvastad, L., Andersson, A., Mollbrink, A., Kokaraki, G., Monteil, V., Schultz, N., Appelberg, K. S., et al. (2021) · Cell Genomics · doi:10.1016/j.xgen.2021.100065 · Cited by 132
Patton, R. D., Sanjeev, M., Woodward, L. A., Mabin, J. W., Bundschuh, R., & Singh, G. (2020) · RNA · doi:10.1261/rna.074856.120 · Cited by 46
Welp, L. M., Wulf, A., Chernev, A., Horokhovskyi, Y., Moshkovskii, S., Dybkov, O., Neumann, P., Pašen, M., Siraj, A., Raabe, M., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf727 · Cited by 12
Metadata
- Authors
- Hoffman, E. A., Frey, B. L., Smith, L. M., & Auble, D. T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 290
- Issue
- 44
- Pages
- 26404-26411
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1826402150
- Cited by
- 441
- References
- 85
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hoffman, E. A., Frey, B. L., Smith, L. M., & Auble, D. T. (2015). Formaldehyde Crosslinking: A Tool for the Study of Chromatin Complexes. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.r115.651679
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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