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Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation
Open accessAbstract
Identifying BAP1 Targets: Inactivating mutations in the deubiquitinating enzyme BAP1 have been associated with cancer. Dey et al. (p. 1541 , published online 9 August; see the Perspective by White and Harper ) reveal molecular targets of the enzyme and show evidence for a role in leukemia. Mice specifically lacking the target of BAP1, HCF-1, in the bone marrow developed myeloid leukemia. BAP1 appears to be part of a complex that regulates modification of histones and gene expression important for normal hematopoiesis and tumor suppression.
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Cites
Fast and SNP-tolerant detection of complex variants and splicing in short reads
Wu, T. D., & Nacu, S. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq057 · Cited by 1,894
Krüger, M., Moser, M., Ussar, S., Thievessen, I., Luber, C. A., Forner, F., Schmidt, S., Zanivan, S., Fässler, R., & Mann, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.033 · Cited by 680
The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1
Machida, Y. J., Machida, Y., Vashisht, A. A., Wohlschlegel, J. A., & Dutta, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.046755 · Cited by 274
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Carbone, M., Yang, H., Pass, H. I., Krausz, T., Testa, J. R., & Gaudino, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3459 · Cited by 590
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Yap, T. A., Aerts, J. G., Popat, S., & Fennell, D. A. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.42 · Cited by 324
Mesothelioma: Scientific clues for prevention, diagnosis, and therapy
Carbone, M., Adusumilli, P. S., Alexander, H. R., Baas, P., Bardelli, F., Bononi, A., Bueno, R., Felley‐Bosco, E., Galateau‐Salle, F., Jablons, D., et al. (2019) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21572 · Cited by 335
Metadata
- Authors
- Dey, A., Seshasayee, D., Noubade, R., French, D. M., Liu, J., Chaurushiya, M. S., Kirkpatrick, D. S., Pham, V. C., Lill, J. R., Bakalarski, C. E., Wu, J., Phu, L., Katavolos, P., LaFave, L. M., Abdel-Wahab, O., Modrusan, Z., Seshagiri, S., Dong, K., Lin, Z., Balazs, M., Suriben, R., Newton, K., Hymowitz, S., Garcia-Manero, G., Martin, F., Levine, R. L., & Dixit, V. M.
- Venue
- Science
- Published
- 2012-09-21
- Volume
- 337
- Issue
- 6101
- Pages
- 1541-1546
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989561383
- Cited by
- 412
- References
- 3
- FWCI
- 24.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Dey, A., Seshasayee, D., Noubade, R., French, D. M., Liu, J., Chaurushiya, M. S., Kirkpatrick, D. S., Pham, V. C., Lill, J. R., Bakalarski, C. E., Wu, J., Phu, L., Katavolos, P., LaFave, L. M., Abdel-Wahab, O., Modrusan, Z., Seshagiri, S., Dong, K., Lin, Z., . . . Dixit, V. M. (2012). Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation. Science. https://doi.org/10.1126/science.1221711
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
