The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Radical SAM-Dependent Carbon Insertion into the Nitrogenase M-Cluster
Open accessAbstract
A Radical Mechanism: The bacterial enzyme nitrogenase plays a key role in the global nitrogen cycle by catalyzing the reduction of N 2 to ammonia. At the heart of the enzyme is a metal-sulfur cluster that contains an interstitial light atom recently identified as a carbide. The identification raised questions concerning the role of the carbide in the enzyme mechanism and how it is inserted into the metal cluster. Wiig et al. (p. 1672 ; see the Perspective by Boal and Rosenzweig ) now show that the carbide derives from S-adenosylmethionine (SAM) and is inserted into the core by the radical SAM enzyme NifB.
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Cites
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Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor
Spatzal, T., Aksoyoglu, M., Zhang, L., Andrade, S. L. A., Schleicher, E., Weber, S., Rees, D. C., & Einsle, O. (2011) · Science · doi:10.1126/science.1214025 · Cited by 914
X-ray Emission Spectroscopy Evidences a Central Carbon in the Nitrogenase Iron-Molybdenum Cofactor
Lancaster, K. M., Roemelt, M., Ettenhuber, P., Hu, Y., Ribbe, M. W., Neese, F., Bergmann, U., & DeBeer, S. (2011) · Science · doi:10.1126/science.1206445 · Cited by 888
Self-citationMolybdenum cofactors, enzymes and pathways
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Cited by
Mechanism of Nitrogen Fixation by Nitrogenase: The Next Stage
Hoffman, B. M., Lukoyanov, D., Yang, Z.-Y., Dean, D. R., & Seefeldt, L. C. (2014) · Chemical Reviews · doi:10.1021/cr400641x · Cited by 1,766
Radical S-Adenosylmethionine Enzymes
Broderick, J. B., Duffus, B. R., Duschene, K. S., & Shepard, E. M. (2014) · Chemical Reviews · doi:10.1021/cr4004709 · Cited by 830
Structural Enzymology of Nitrogenase Enzymes
Einsle, O., & Rees, D. C. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00067 · Cited by 409
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401
Recent developments in the homogeneous reduction of dinitrogen by molybdenum and iron
MacLeod, K. C., & Holland, P. L. (2013) · Nature Chemistry · doi:10.1038/nchem.1620 · Cited by 398
Metadata
- Authors
- Wiig, J. A., Hu, Y., Lee, C. C., & Ribbe, M. W.
- Venue
- Science
- Published
- 2012-09-28
- Volume
- 337
- Issue
- 6102
- Pages
- 1672-1675
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010267925
- Cited by
- 271
- References
- 23
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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