The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Genomic Analysis of Non- NF2 Meningiomas Reveals Mutations in TRAF7 , KLF4 , AKT1 , and SMO
Open accessAbstract
Genetic Clues to Meningioma: Meningiomas are the most common primary brain tumors in adults. Located within the layer of tissue covering the brain, these tumors are usually slow-growing and benign but can cause serious neurological complications. About half of these tumors have mutations in the neurofibromin 2 gene ( NF2 ). To identify other genes that contribute to meningioma pathogenesis, Clark et al. (p. 1077 , published online 24 January) performed genome sequence analysis on 300 tumors. Meningiomas fell into two general classes: benign tumors located at the skull base—which tend to harbor mutations in the TRAF7, KLF4, AKT1 , and SMO genes—and higher-grade tumors located in the cerebral and cerebellar hemispheres harbor mutations in NF2.
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Metadata
- Authors
- Clark, V. E., Erson-Omay, E. Z., Serin, A., Yin, J., Cotney, J., Özduman, K., Avşar, T., Li, J., Murray, P. B., Henegariu, O., Yilmaz, S., Günel, J. M., Carrión-Grant, G., Yılmaz, B., Grady, C., Tanrıkulu, B., Bakırcıoğlu, M., Kaymakçalan, H., Caglayan, A. O., Sencar, L., Ceyhun, E., Atik, A. F., Bayri, Y., Bai, H., Kolb, L. E., Hebert, R. M., Omay, S. B., Mishra-Gorur, K., Choi, M., Overton, J. D., Holland, E. C., Mane, S., State, M. W., Bilgüvar, K., Baehring, J. M., Gutin, P. H., Piepmeier, J. M., Vortmeyer, A., Brennan, C. W., Pamir, M. N., Kılıç, T., Lifton, R. P., Noonan, J. P., Yasuno, K., & Günel, M.
- Venue
- Science
- Published
- 2013-03
- Volume
- 339
- Issue
- 6123
- Pages
- 1077-1080
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000381516
- Cited by
- 912
- References
- 8
- FWCI
- 38.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Clark, V. E., Erson-Omay, E. Z., Serin, A., Yin, J., Cotney, J., Özduman, K., Avşar, T., Li, J., Murray, P. B., Henegariu, O., Yilmaz, S., Günel, J. M., Carrión-Grant, G., Yılmaz, B., Grady, C., Tanrıkulu, B., Bakırcıoğlu, M., Kaymakçalan, H., Caglayan, A. O., . . . Günel, M. (2013). Genomic Analysis of Non- NF2 Meningiomas Reveals Mutations in TRAF7 , KLF4 , AKT1 , and SMO. Science. https://doi.org/10.1126/science.1233009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
