Role of Macrophages in Brain Tumor Growth and Progression
Open accessAbstract
The role of macrophages in the growth and the progression of tumors has been extensively studied in recent years. A large body of data demonstrates that macrophage polarization plays an essential role in the growth and progression of brain tumors, such as gliomas, meningiomas, and medulloblastomas. The brain neoplasm cells have the ability to influence the polarization state of the tumor associated macrophages. In turn, innate immunity cells have a decisive role through regulation of the acquired immune response, but also through humoral cross-talking with cancer cells in the tumor microenvironment. Neoangiogenesis, which is an essential element in glial tumor progression, is even regulated by the tumor associated macrophages, whose activity is linked to other factors, such as hypoxia. In addition, macrophages play a decisive role in establishing the entry into the bloodstream of cancer cells. As is well known, the latter phenomenon is also present in brain tumors, even if they only rarely metastasize. Looking ahead in the future, we can imagine that characterizing the relationships between tumor and tumor associated macrophage, as well as the study of circulating tumor cells, could give us useful tools in prognostic evaluation and therapy. More generally, the study of innate immunity in brain tumors can boost the development of new forms of immunotherapy.
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Gliomas and meningiomas are the most common form of tumors and originate from the cerebrum and supportive tissues of the brain.
“Gliomas and meningiomas are the most common form of tumors [43] and originate from the cerebrum and supportive tissues of the brain [42,86].”
From A Comprehensive Analysis of Recent Deep and Federated-Learning-Based Methodologies for Brain Tumor Diagnosis (2022) · cites this paper as [86]
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Flagged first, then by citations
Research works printed but not linked: 1
- [23]Mills S.E. Histology for Pathologists 3rd ed. Lippincott Philadelphia, PA, USA 2007 298 299 978-1451113037
Cited by
Sorted by citations
Naeem, A., Anees, T., Naqvi, R. A., & Loh, W.-K. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020275 · Cited by 103 · see citing works
- Authors
- Guadagno, E., Presta, I., Maisano, D., Donato, A., Pirrone, C., Cardillo, G., Corrado, S., Mignogna, C., Mancuso, T., Donato, G., Del Basso De Caro, M., & Malara, N.
- Affiliations
- University of Naples Federico II (IT)
- Magna Graecia University (IT)
- Department of Health Sciences, University of Catanzaro “Magna Græcia”—viale Europa, 88100 Catanzaro, Italy
- Department of Advanced Biomedical Sciences—Pathology Section, University of Naples “Federico II”—via Pansini 5, 80131 Naples, Italy
- Corresponding author
- Donato, Giuseppe
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-03-27
- Volume
- 19
- Issue
- 4
- Pages
- 1005
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5979398
- OpenAlex
- W2795168220
- Cited by
- 118
- References
- 137
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 19 · 2023: 13 · 2022: 13 · 2021: 21 · 2020: 24 · 2019: 8 · 2018: 4
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- tumor-associated macrophages, macrophage polarization, brain tumors, glioma, meningioma, medulloblastoma, tumor microenvironment, neoangiogenesis, hypoxia, cancer cell dissemination, circulating tumor cells, innate immunity, cancer immunotherapy, tumor progression
- MeSH terms
- Animals, Brain Neoplasms, Humans, Macrophage Activation, Macrophages, Neoplastic Cells, Circulating, Prognosis, Cell Hypoxia, Cell Polarity, Disease Progression
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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