Cited by 292Evolution and Genetic DynamicsGenetic diversity and population structureAnimal Behavior and Reproduction

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Adaptive Evolution of Multiple Traits Through Multiple Mutations at a Single Gene

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Linnen, Catherine R., Poh, Yu-Ping, Peterson, Brant K., Barrett, Rowan D. H., Larson, Joanna G., Jensen, Jeffrey D., Hoekstra, Hopi E.·2013·Science

DOI 10.1126/science.1233213PMC PMC3836219

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Abstract

The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.

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Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
The genetical theory of natural selection
Fisher, R. A. (1930) · doi:10.5962/bhl.title.27468 · Cited by 17,617
Fast and accurate long-read alignment with Burrows-Wheeler transform.
Li, H., & Durbin, R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp698 · Cited by 12,063
A framework for variation discovery and genotyping using next-generation DNA sequencing data
DePristo, M. A., Banks, E., Poplin, R. E., Garimella, K. V., Maguire, J., Hartl, C., Philippakis, A., del Angel, G., Rivas, M. A., Hanna, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.806 · Cited by 11,457
On the origin of species by means of natural selection, or, The preservation of favoured races in the struggle for life /
Darwin, C. R., Darwin, C. R., & Edmonds & Remnants (1859) · J. Murray eBooks · doi:10.5962/bhl.title.59991 · Cited by 7,020
On the origin of species by means of natural selection, or, The preservation of favoured races in the struggle for life
Darwin, C. R., Murray, J. J., Sons, W. C. A., & Evans., B. &. (1859) · Biodiversity Heritage Library (Smithsonian Institution) · doi:10.5962/bhl.title.82303 · Cited by 5,668
Population Structure and Eigenanalysis
Patterson, N., Price, A. L., & Reich, D. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020190 · Cited by 5,280
spag e d i: a versatile computer program to analyse spatial genetic structure at the individual or population levels
Hardy, O. J., & Vekemans, X. (2002) · Molecular Ecology Notes · doi:10.1046/j.1471-8286.2002.00305.x · Cited by 3,591

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Dice L. R., Variation of the deer-mouse (Peromyscus maniculatus) on the Sand Hills of Nebraska and adjacent areas. Contrib. Lab. Vertebr. Genet. Univ. Mich. 15, 1 (1941).
Dice L. R., Effectiveness of selection by owls of deer-mice (Peromyscus maniculatus) which contrast in color with their background. Contrib. Lab. Vertebr. Biol. Univ. Mich. 34, 1 (1947).

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Intra-specific pelage color variation in a South American small rodent species.
Sandoval-Salinas, M. L., Barquez, R., Colombo, E., & Sandoval, J. (2017) · Brazilian journal of biology = Revista brasleira de biologia · doi:10.1590/1519-6984.00615 · Cited by 13
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Evolutionary physiology at 30+: Has the promise been fulfilled?
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A mosaic of modular variation at a single gene underpins convergent plumage coloration
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Multi‐Omics‐Driven Adaptive Management of Biological Invasions: Toward a Proactive, Predictive, and Integrative Framework
Zhan, A. (2025) · Biological Diversity · doi:10.1002/bod2.70015 · Cited by 12
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Ray, R., Halitschke, R., Gase, K., Leddy, S. M., Schuman, M. C., Rodde, N., & Baldwin, I. T. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2308500120 · Cited by 12
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Genomic basis of evolutionary change: evolving immunity
Wertheim, B. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00222 · Cited by 12
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Differential Gene Expression in the Human Brain Is Associated with Conserved, but Not Accelerated, Noncoding Sequences
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Signatures of soft sweeps across the Dt1 locus underlying determinate growth habit in soya bean [Glycine max (L.) Merr.]
Zhong, L., Yang, Q., Yan, X., Yu, C., Liu, S., Zhang, X., & Zhu, Y. (2017) · Molecular Ecology · doi:10.1111/mec.14209 · Cited by 12
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Etges, W. J. (2014) · Journal of Heredity · doi:10.1093/jhered/esu039 · Cited by 11
Limb segment contributions to the evolution of hind limb length in phrynosomatid lizards
Olberding, J. P., Herrel, A., Higham, T. E., & Garland, T. (2015) · Biological Journal of the Linnean Society · doi:10.1111/bij.12709 · Cited by 11
Embryonic Development of the Deer Mouse, Peromyscus maniculatus
Davis, S. W., & Keisler, J. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150598 · Cited by 11
Crossing extreme habitat boundaries: Jack‐of‐all‐trades facilitates invasion but is eroded by adaptation to a master‐of‐one
Ord, T. J., & Hundt, P. J. (2020) · Functional Ecology · doi:10.1111/1365-2435.13600 · Cited by 11
The shape of things to come in the study of the origin of species?
Rogers, S. M., & Jamniczky, H. A. (2014) · Molecular Ecology · doi:10.1111/mec.12695 · Cited by 10
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Differential responses of avian and mammalian predators to phenotypic variation in Australian Brood Frogs
Lawrence, J. P., Mahony, M. J., & Noonan, B. P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195446 · Cited by 10
The role of spatial structure in multi‐deme models of evolutionary rescue
Tomasini, M., & Peischl, S. (2022) · Journal of Evolutionary Biology · doi:10.1111/jeb.14018 · Cited by 9

Authors: Linnen, C. R., Poh, Y.-P., Peterson, B. K., Barrett, R. D. H., Larson, J. G., Jensen, J. D., & Hoekstra, H. E.
Affiliations: University of Kentucky (US)
SIB Swiss Institute of Bioinformatics (CH)
Harvard University (US)
Corresponding author: Linnen, Catherine R.
Hoekstra, Hopi E.
ORCID: Linnen, Catherine R.
Peterson, Brant K.
Barrett, Rowan D. H.
Larson, Joanna G.
Jensen, Jeffrey D.
Hoekstra, Hopi E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2013-03-15
Volume: 339
Issue: 6125
Pages: 1312-1316
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1233213
PMC: PMC3836219
OpenAlex: W1977765763
Cited by: 292
References: 45
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 21 · 2022: 11 · 2021: 25 · 2020: 17 · 2019: 24 · 2018: 30 · 2017: 27 · 2016: 31 · 2015: 27 · 2014: 41 · 2013: 18
FWCI: 25.88
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords: local adaptation, agouti locus, coat color, deer mouse, Nebraska Sandhills, visual predation, predation selection, pleiotropy, haplotype selection, color polymorphism, phenotypic plasticity
MeSH terms: Adaptation, Physiological, Animals, Color, Biological Evolution, Mutation, Organic Chemicals, Peromyscus, Pigmentation, Selection, Genetic, Food Chain, Multifactorial Inheritance, Agouti Signaling Protein

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Adaptive Evolution of Multiple Traits Through Multiple Mutations at a Single Gene

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