The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome
Open accessAbstract
Understanding Xist-ance: Large noncoding RNAs (lncRNAs) are increasingly appreciated to play important roles in the cell. A number of lncRNAs act to target chromatin regulatory complexes to their sites of action. Engreitz et al. (p. 10.1126/science.1237973 , published online 4 July; see the Perspective by Dimond and Fraser ) found that the mouse Xist lncRNA, which initiates X-chromosome inactivation, was transferred from its site of transcription to distant sites on the X chromosome purely through their close three-dimensional proximity to the Xist gene. Xist initially localized to the periphery of active genes on the X chromosome but gradually spread across them using its A-repeat domain, until the Xist RNA bound broadly across the inactive X chromosome in differentiated female cells.
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Cites
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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Self-citationLong Noncoding RNA as Modular Scaffold of Histone Modification Complexes
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“One emerging paradigm is that many lncRNAs can regulate gene expression (6, 8-11) by interacting with chromatin regulatory complexes (6, 12-14) and localizing these complexes to genomic target sites (15-17).”
BackgroundLong Noncoding RNAs with Enhancer-like Function in Human Cells
Ørom, U. A., Derrien, T., Beringer, M., Gumireddy, K., Gardini, A., Bussotti, G., Lai, F., Zytnicki, M., Notredame, C., Huang, Q., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.001 · Cited by 1,721
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Self-citationExploring the three-dimensional organization of genomes: Interpreting chromatin interaction data
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Genes that escape from X inactivation
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Global survey of escape from X inactivation by RNA-sequencing in mouse
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Cited by
Gene regulation by long non-coding RNAs and its biological functions
Statello, L., Guo, C.-J., Chen, L.-L., & Huarte, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00315-9 · Cited by 4,991
Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083
Genetic screens in human cells using the CRISPR-Cas9 system
Wang, T., Wei, J. J., Sabatini, D. M., & Lander, E. S. (2014) · Science · doi:10.1126/science.1246981 · Cited by 2,856
Self-citationGenetic and epigenetic fine mapping of causal autoimmune disease variants
Farh, K. K.-H., Marson, A., Zhu, J., Kleinewietfeld, M., Housley, W. J., Beik, S., Shoresh, N., Whitton, H., Ryan, R. J. H., Shishkin, A. A., et al. (2015) · Nature · doi:10.1038/nature13835 · Cited by 1,956
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Metadata
- Authors
- Engreitz, J. M., Pandya-Jones, A., McDonel, P., Shishkin, A., Sirokman, K., Surka, C., Kadri, S., Xing, J., Goren, A., Lander, E. S., Plath, K., & Guttman, M.
- Venue
- Science
- Published
- 2013-08-16
- Volume
- 341
- Issue
- 6147
- Pages
- 1237973-1237973
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1535005173
- Cited by
- 983
- References
- 9
- FWCI
- 34.83
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome. https://app.cochat.ai/papers/10.1126/science.1237973
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- Engreitz, J. M., Pandya-Jones, A., McDonel, P., Shishkin, A., Sirokman, K., Surka, C., Kadri, S., Xing, J., Goren, A., Lander, E. S., Plath, K., & Guttman, M. (2013). The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome. Science. https://doi.org/10.1126/science.1237973
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