Nuclear Wave1 Is Required for Reprogramming Transcription in Oocytes and for Normal Development
Open accessAbstract
Egg WAVE1: Eggs not only activate sperm nuclei for normal development but also reprogram transplanted somatic nuclei. In addition to its well-established cytoplasmic role in actin organization, Miyamoto et al. (p. 1002 ) discovered that the Wiskott-Aldrich syndrome protein family member 1 in oocytes cooperates with transcriptional machineries in the nucleus to activate previously silenced genes.
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Nuclear WAVE1 was identified as a central regulator of the transcriptional reprogramming required for Xenopus oocyte development.
“Nuclear WAVE1 was identified as a central regulator of the transcriptional reprogramming required for Xenopus oocyte development86.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [86]
The paper reports that nuclear Wave1 is necessary for efficient transcriptional reprogramming in Xenopus oocytes (passage 2). It links Wave1 to normal embryonic development, however, rather than showing that this reprogramming is required for oocyte development (passages 1 and 5). (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe role of nuclear WAVE1 in gene activation during development is likely mediated by its WAVE homology domain, indicating the potential involvement of other subunits of the WAVE complex in nuclear programming.
“The role of nuclear WAVE1 in gene activation during development is likely mediated by its WAVE homology domain (WHD), indicating the potential involvement of other subunits of the WAVE complex in nuclear programming86.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [86]
The passage labeled Abstract (page not given) says nuclear Wave1 acts through its WHD domain, which mediates interaction with transcription regulators and affects hox-gene activation. It does not identify other WAVE-complex subunits or suggest that they participate in nuclear programming; that part is an inference beyond the paper's stated findings. (LLM, conf=0.84)
Experimental — accuracy not yet measuredWAVE1 knockdown in embryos results in defective Hox gene activation and abnormal development.
“WAVE1 knockdown in embryos results in defective Hox gene activation and abnormal development.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [86]
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Research works printed but not linked: 18
- [1]Jullien J Pasque V Halley-Stott RP Miyamoto K Gurdon JB Nat. Rev. Mol. Cell Biol 2011 12 453 459 21697902 PMC3657683
- [2]Kim K Nature 2010 467 285 290 20644535 PMC3150836
- [3]Gao S Biol. Reprod 2002 67 928 934 12193404
- [4]Ogushi S Science 2008 319 613 616 18239124
- [5]Miyamoto K Pasque V Jullien J Gurdon JB Genes Dev 2011 25 946 958 21536734 PMC3084028
- [6]Campellone KG Welch MD Nat. Rev. Mol. Cell 2010 11 237 251 PMC2929822 20237478
- [7]Taylor MD Sci. Transl. Med 2010 2 37ra44 PMC2943146 20574068
- [8]Wu X Nat. Cell Biol 2006 8 756 763 16767080
- [9]Ferrai C Mol. Biol. Cell 2009 20 3543 3551 19477923 PMC2719572
- [11]Fricke R Curr. Biol 2009 19 1429 1437 19716703
- [12]Ho HY Cell 2004 118 203 216 15260990
- [13]Miki H Suetsugu S Takenawa T EMBO J 1998 17 6932 6941 9843499 PMC1171041
- [14]Gurdon JB J. Embryol. Exp. Morphol 1968 20 401 414 5750105
- [15]Koche RP Cell Stem Cell 2011 8 96 105 21211784 PMC3220622
- [16]Hulstrand AM Schneider PN Houston DW Methods 2010 51 75 81 20045732 PMC2868083
- [17]Rawe VY Payne C Navara C Schatten G Dev. Biol 2004 276 253 267 15581863
- [18]Takenawa T Suetsugu S Nat. Rev. Mol. Cell Biol 2007 8 37 48 17183359
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The WAVE complex in developmental and adulthood brain disorders
Kim, H.-G., Berdasco, C., Nairn, A. C., & Kim, Y. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01386-w · Cited by 8 · see citing works
- Authors
- Miyamoto, K., Teperek, M., Yusa, K., Allen, G. E., Bradshaw, C. R., & Gurdon, J. B.
- Affiliations
- University of Cambridge (GB)
- Wellcome Sanger Institute (GB)
- Corresponding author
- Miyamoto, Kei
- Gurdon, J. B.
- Venue
- Science
- Published
- 2013-08-30
- Volume
- 341
- Issue
- 6149
- Pages
- 1002-1005
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3824084
- OpenAlex
- W2057429454
- Cited by
- 91
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 2 · 2020: 10 · 2019: 7 · 2018: 4 · 2017: 10 · 2016: 7 · 2015: 11 · 2014: 12 · 2013: 1
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (101050, 089613, 101050/Z/13/Z, WT077187, 092096, WT089613, 088333)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- WAVE1, Xenopus, RNA polymerase II, actin-binding proteins, nuclear actin, somatic cell nuclear transfer, embryonic development, gene activation
- MeSH terms
- Animals, Cell Nucleus, Female, Genes, Homeobox, Nuclear Proteins, Oocytes, RNA Polymerase II, Transcription, Genetic, Xenopus laevis, Transcriptional Activation, Protein Structure, Tertiary, Gene Expression Regulation, Developmental, Xenopus Proteins, Wiskott-Aldrich Syndrome Protein Family, Mice, Gene Knockdown Techniques, Cellular Reprogramming
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