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Cited by 1,616

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

Kuida, Keisuke, Lippke, Judith A., Ku, George, Harding, Matthew W., Livingston, David J., Su, Michael S.-S., Flavell, Richard A.·1995·Science
DOI 10.1126/science.7535475
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Abstract

The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE -/- ) did not export IL-1β or interleukin-1α (IL-1α) after stimulation with lipopolysaccharide. Export of tumor necrosis factor-α and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes from ICE -/- mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect in apoptosis, ICE -/- mice proceed normally through development.

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Research works printed but not linked: 38

  1. Auron, P., Proceedings of the National Academy of Sciences of the United States of America 81: 7907 (1984).
  2. BLACK, R.A., ACTIVATION OF INTERLEUKIN-1-BETA BY A CO-INDUCED PROTEASE, FEBS LETTERS 247: 386 (1989). · DOI · Paper page
  3. BLACK, R.A., GENERATION OF BIOLOGICALLY-ACTIVE INTERLEUKIN-1-BETA BY PROTEOLYTIC CLEAVAGE OF THE INACTIVE PRECURSOR, JOURNAL OF BIOLOGICAL CHEMISTRY 263: 9437 (1988). · DOI · Paper page
  4. BRUNNER, T, CELL-AUTONOMOUS FAS (CD95) FAS-LIGAND INTERACTION MEDIATES ACTIVATION-INDUCED APOPTOSIS IN T-CELL HYBRIDOMAS, NATURE 373: 441 (1995). · DOI · Paper page
  5. CARRUTH, L.M., INVOLVEMENT OF A CALPAIN-LIKE PROTEASE IN THE PROCESSING OF THE MURINE INTERLEUKIN-1-ALPHA PRECURSOR, JOURNAL OF BIOLOGICAL CHEMISTRY 266: 12162 (1991). · DOI
  6. CASANO, F.J., THE STRUCTURE AND COMPLETE NUCLEOTIDE-SEQUENCE OF THE MURINE GENE ENCODING INTERLEUKIN-1-BETA CONVERTING-ENZYME (ICE), GENOMICS 20: 474 (1994). · DOI
  7. 10.1038/362849a0 · DOI · Paper page
  8. COHEN, J.J., GLUCOCORTICOID ACTIVATION OF A CALCIUM-DEPENDENT ENDONUCLEASE IN THYMOCYTE NUCLEI LEADS TO CELL-DEATH, JOURNAL OF IMMUNOLOGY 132: 38 (1984). · DOI · Paper page
  9. DHEIN, J, AUTOCRINE T-CELL SUICIDE MEDIATED BY APO-1/(FAS/CD95), NATURE 373: 438 (1995). · DOI · Paper page
  10. FERNANDESALNEMR.T, J BIOL CHEM 269: 30761 (1994). · DOI · Paper page
  11. 10.1126/science.8303301 · DOI · Paper page
  12. HAZUDA, D.J., PROCESSING OF PRECURSOR INTERLEUKIN-1-BETA AND INFLAMMATORY DISEASE, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 6318 (1990). · DOI · Paper page
  13. HOWARD, A.D., IL-1-CONVERTING ENZYME REQUIRES ASPARTIC-ACID RESIDUES FOR PROCESSING OF THE IL-1-BETA PRECURSOR AT 2 DISTINCT SITES AND DOES NOT CLEAVE 31-KDA IL-1-ALPHA, JOURNAL OF IMMUNOLOGY 147: 2964 (1991). · DOI · Paper page
  14. ITOH, N, THE POLYPEPTIDE ENCODED BY THE CDNA FOR HUMAN CELL-SURFACE ANTIGEN FAS CAN MEDIATE APOPTOSIS, CELL 66: 233 (1991). · DOI · Paper page
  15. JU, S.T., FAS(CD95) FASL INTERACTIONS REQUIRED FOR PROGRAMMED CELL-DEATH AFTER T-CELL ACTIVATION, NATURE 373: 444 (1995). · DOI · Paper page
  16. JU, S.T., PARTICIPATION OF TARGET FAS PROTEIN IN APOPTOSIS PATHWAY INDUCED BY CD4(+) TH1 AND CD8(+) CYTOTOXIC T-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 4185 (1994).
  17. KOBAYASHI, Y, IDENTIFICATION OF CALCIUM-ACTIVATED NEUTRAL PROTEASE AS A PROCESSING ENZYME OF HUMAN INTERLEUKIN-1-ALPHA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 5548 (1990).
  18. KUMAR, S, INDUCTION OF APOPTOSIS BY THE MOUSE NEDD2 GENE, WHICH ENCODES A PROTEIN SIMILAR TO THE PRODUCT OF THE CAENORHABDITIS-ELEGANS CELL-DEATH GENE CED-3 AND THE MAMMALIAN IL-1-BETA-CONVERTING ENZYME, GENES & DEVELOPMENT 8: 1613 (1994). · DOI · Paper page
  19. MIURA, M, INDUCTION OF APOPTOSIS IN FIBROBLASTS BY IL-1-BETA-CONVERTING ENZYME, A MAMMALIAN HOMOLOG OF THE C-ELEGANS CELL-DEATH GENE CED-3, CELL 75: 653 (1993). · DOI · Paper page
  20. MOLINEAUX, S.M., INTERLEUKIN-1-BETA (IL-1-BETA) PROCESSING IN MURINE MACROPHAGES REQUIRES A STRUCTURALLY CONSERVED HOMOLOG OF HUMAN IL-1-BETA CONVERTING ENZYME, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 1809 (1993).
  21. NAKAYAMA, K, DISAPPEARANCE OF THE LYMPHOID SYSTEM IN BCL-2 HOMOZYGOUS MUTANT CHIMERIC MICE, SCIENCE 261: 1584 (1993). · DOI · Paper page
  22. PERREGAUX, D, INTERLEUKIN-1-BETA MATURATION AND RELEASE IN RESPONSE TO ATP AND NIGERICIN - EVIDENCE THAT POTASSIUM-DEPLETION MEDIATED BY THESE AGENTS IS A NECESSARY AND COMMON FEATURE OF THEIR ACTIVITY, JOURNAL OF BIOLOGICAL CHEMISTRY 269: 15195 (1994). · DOI · Paper page
  23. PERREGAUX, D, IL-1-BETA MATURATION - EVIDENCE THAT MATURE CYTOKINE FORMATION CAN BE INDUCED SPECIFICALLY BY NIGERICIN, JOURNAL OF IMMUNOLOGY 149: 1294 (1992). · DOI
  24. RAY, C.A., VIRAL INHIBITION OF INFLAMMATION - COWPOX VIRUS ENCODES AN INHIBITOR OF THE INTERLEUKIN-1-BETA CONVERTING ENZYME, CELL 69: 597 (1992). · DOI · Paper page
  25. SENTMAN, C.L., BCL-2 INHIBITS MULTIPLE FORMS OF APOPTOSIS BUT NOT NEGATIVE SELECTION IN THYMOCYTES, CELL 67: 879 (1991). · DOI · Paper page
  26. SIDERS, W.M., CHARACTERIZATION OF THE STRUCTURAL REQUIREMENTS AND CELL-TYPE SPECIFICITY OF IL-1-ALPHA AND IL-1-BETA SECRETION, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 22170 (1993). · doi:10.1016/s0021-9258(20)80663-2
  27. SLEATH, P.R., SUBSTRATE-SPECIFICITY OF THE PROTEASE THAT PROCESSES HUMAN INTERLEUKIN-1-BETA, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 14526 (1990). · DOI
  28. THOMAS, K.R., SITE-DIRECTED MUTAGENESIS BY GENE TARGETING IN MOUSE EMBRYO-DERIVED STEM-CELLS, CELL 51: 503 (1987). · DOI · Paper page
  29. THORNBERRY, N.A., A NOVEL HETERODIMERIC CYSTEINE PROTEASE IS REQUIRED FOR INTERLEUKIN-1-BETA PROCESSING IN MONOCYTES, NATURE 356: 768 (1992). · DOI · Paper page
  30. 10.1126/science.1470921 · DOI · Paper page
  31. 10.1016/0092-8674(93)80065-M · DOI · Paper page
  32. VOELKELJOHNSON, C, ACTIVATION OF INTRACELLULAR PROTEASES IS AN EARLY EVENT IN TNF-INDUCED APOPTOSIS, JOURNAL OF IMMUNOLOGY 154: 1707 (1995). · DOI
  33. WALKER, NPC, CRYSTAL-STRUCTURE OF THE CYSTEINE PROTEASE INTERLEUKIN-1-BETA-CONVERTING ENZYME - A (P20/P10)(2) HOMODIMER, CELL 78: 343 (1994). · DOI · Paper page
  34. 10.1016/S0092-8674(94)90422-7 · DOI · Paper page
  35. WATANABEFUKUNAG.R, LYMPHOPROLIFERATION DISORDER IN MICE EXPLAINED BY DEFECTS IN FAS ANTIGEN THAT MEDIATES APOPTOSIS, NATURE 356: 314 (1992). · DOI · Paper page
  36. WEAVER, V. M., BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 71: 488 (1993). · DOI
  37. WILSON, K.P., STRUCTURE AND MECHANISM OF INTERLEUKIN-1-BETA CONVERTING-ENZYME, NATURE 370: 270 (1994). · DOI · Paper page
  38. 10.1016/0092-8674(93)90485-9 · DOI · Paper page

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Metadata

Authors
Kuida, K., Lippke, J. A., Ku, G., Harding, M. W., Livingston, D. J., Su, M. S.-S., & Flavell, R. A.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1995-03-31
Volume
267
Issue
5206
Pages
2000-2003
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7535475
OpenAlex
W1964977785
Cited by
1,616
References
3
FWCI
46.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme. https://app.cochat.ai/papers/10.1126/science.7535475
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Kuida, K., Lippke, J. A., Ku, G., Harding, M. W., Livingston, D. J., Su, M. S.-S., & Flavell, R. A. (1995). Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme. Science. https://doi.org/10.1126/science.7535475

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