The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
14-Step Synthesis of (+)-Ingenol from (+)-3-Carene
Abstract
Ingenol Ingenuity: The diterpenoid i ngenol is the core structure of a topical drug recently commercialized to treat actinic keratosis, a precancerous skin condition. Sourcing the compound from the Euphorbia plants that produce it is relatively inefficient, so Jørgensen et al. (p. 878 , published online 1 August) devised a chemical synthesis starting from the comparatively simple and inexpensive monoterpene chiral (+)-3-carene. The synthetic sequence involves 14 steps—less than half as long as prior chemical routes to the target—and relies on a two-stage approach, inspired by the posited biosynthetic pathway, in which preliminary assembly of the fused ring framework precedes hydroxylation of the periphery.
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Self-citationAntitumor Activity of 3-Ingenyl Angelate
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Modulators of Protein–Protein Interactions
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Lauersen, K. J., Wichmann, J., Baier, T., Kampranis, S. C., Pateraki, I., Møller, B. L., & Kruse, O. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.07.005 · Cited by 124
Metadata
- Authors
- Jørgensen, L., McKerrall, S. J., Kuttruff, C. A., Ungeheuer, F., Felding, J., & Baran, P. S.
- Venue
- Science
- Published
- 2013-08-23
- Volume
- 341
- Issue
- 6148
- Pages
- 878-882
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024258562
- Cited by
- 347
- References
- 13
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jørgensen, L., McKerrall, S. J., Kuttruff, C. A., Ungeheuer, F., Felding, J., & Baran, P. S. (2013). 14-Step Synthesis of (+)-Ingenol from (+)-3-Carene. Science. https://doi.org/10.1126/science.1241606
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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