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Cited by 761

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

Seder, Robert A., Chang, Lee-Jah, Enama, Mary E., Zephir, Kathryn L., Sarwar, Uzma N., Gordon, Ingelise J., Holman, LaSonji A., James, Eric R., Billingsley, Peter F., Gunasekera, Anusha, Richman, Adam, Chakravarty, Sumana, Manoj, Anita, Velmurugan, Soundarapandian, Li, MingLin, Ruben, Adam J., Li, Tao, Eappen, Abraham G., Stafford, Richard E., Plummer, Sarah H., Hendel, Cynthia S., Novik, Laura, Costner, Pamela J. M., Mendoza, Floreliz H., Saunders, Jamie G., Nason, Martha C., Richardson, Jason H., Murphy, Jittawadee, Davidson, Silas A., Richie, Thomas L., Sedegah, Martha, Sutamihardja, Awalludin, Fahle, Gary A., Lyke, Kirsten E., Laurens, Matthew B., Roederer, Mario, Tewari, Kavita, Epstein, Judith E., Sim, B. Kim Lee, Ledgerwood, Julie E., Graham, Barney S., Hoffman, Stephen L., the VRC 312 Study Team, DiGiovanni, Cassandra, Williams, Pernell, Luongo, Nicole, Mitchell, Jillian, Florez, Maria Burgos, Larkin, Brenda, Berkowitz, Nina, Wilson, Brandon, Clarke, Tanya, Vasilenko, Olga, Yamshchikov, Galina, Sitar, Sandra, Stanford, LaChonne, Pittman, Iris, Bailer, Robert T., Casazza, Joseph, Decederfelt, Hope, Starling, Judith, Williams, Esther C., Lau, Anna, Antonara, Stella, Brocious, Jeffery, Kemp, Margaret, Inglese, James, Dranchak, Patricia, Abot, Esteban N., Reyes, Sharina, Ganeshan, Harini, Belmonte, Maria, Huang, Jun, Belmonte, Arnel, Komisar, Jack, Abebe, Yonas, Getachew, Yeab, Patil, Asha, Matheny, Steve, Nelson, Keith, Overby, James, Pich, Virak, Wen, Yingda, Fan, Richard, Fomumbod, Enni, Awe, Aderonke, Chakiath, Chinnamma, King, Mary, Orozco, Maria Socorro, Murshedkar, Tooba, Padilla, Debbie, Jiang, Bing, Gao, Lixin, KC, Natasha, Xu, Rui, Adams, Matthew, Plowe, Christopher, Loblein, Hayley, Renehan, Phyllis Zaia, Kunchai, Meghan, Diep, Ly·2013·Science
DOI 10.1126/science.1241800
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Abstract

Malaria Sporozoite Vaccine: Each year, hundreds of millions of people are infected with Plasmodium falciparum , the mosquito-borne parasite that causes malaria. A preventative vaccine is greatly needed. Seder et al. (p. 1359 , published online 8 August; see the Perspective by Good ) now report the results from a phase I clinical trial where subjects were immunized intravenously with a whole, attenuated sporozoite vaccine. Three of 9 subjects who received four doses and zero of 6 subjects who received five doses of the vaccine went on to develop malaria after controlled malaria infection. Both antibody titers and cellular immune responses correlated positively with the dose of vaccine received, suggesting that both arms of the adaptive immune response may have participated in the observed protection.

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Authors
Seder, R. A., Chang, L.-J., Enama, M. E., Zephir, K. L., Sarwar, U. N., Gordon, I. J., Holman, L. A., James, E. R., Billingsley, P. F., Gunasekera, A., Richman, A., Chakravarty, S., Manoj, A., Velmurugan, S., Li, M., Ruben, A. J., Li, T., Eappen, A. G., Stafford, R. E., Plummer, S. H., Hendel, C. S., Novik, L., Costner, P. J. M., Mendoza, F. H., Saunders, J. G., Nason, M. C., Richardson, J. H., Murphy, J., Davidson, S. A., Richie, T. L., Sedegah, M., Sutamihardja, A., Fahle, G. A., Lyke, K. E., Laurens, M. B., Roederer, M., Tewari, K., Epstein, J. E., Sim, B. K. L., Ledgerwood, J. E., Graham, B. S., Hoffman, S. L., the VRC 312 Study Team, DiGiovanni, C., Williams, P., Luongo, N., Mitchell, J., Florez, M. B., Larkin, B., Berkowitz, N., Wilson, B., Clarke, T., Vasilenko, O., Yamshchikov, G., Sitar, S., Stanford, L., Pittman, I., Bailer, R. T., Casazza, J., Decederfelt, H., Starling, J., Williams, E. C., Lau, A., Antonara, S., Brocious, J., Kemp, M., Inglese, J., Dranchak, P., Abot, E. N., Reyes, S., Ganeshan, H., Belmonte, M., Huang, J., Belmonte, A., Komisar, J., Abebe, Y., Getachew, Y., Patil, A., Matheny, S., Nelson, K., Overby, J., Pich, V., Wen, Y., Fan, R., Fomumbod, E., Awe, A., Chakiath, C., King, M., Orozco, M. S., Murshedkar, T., Padilla, D., Jiang, B., Gao, L., KC, N., Xu, R., Adams, M., Plowe, C., Loblein, H., Renehan, P. Z., Kunchai, M., & Diep, L.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2013-09-20
Volume
341
Issue
6152
Pages
1359-1365
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1241800
OpenAlex
W2119855808
Cited by
761
References
3
FWCI
87.92
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine. https://app.cochat.ai/papers/10.1126/science.1241800
The paper
Seder, R. A., Chang, L.-J., Enama, M. E., Zephir, K. L., Sarwar, U. N., Gordon, I. J., Holman, L. A., James, E. R., Billingsley, P. F., Gunasekera, A., Richman, A., Chakravarty, S., Manoj, A., Velmurugan, S., Li, M., Ruben, A. J., Li, T., Eappen, A. G., Stafford, R. E., . . . Diep, L. (2013). Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine. Science. https://doi.org/10.1126/science.1241800

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.