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Cited by 604

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

High-Resolution Mapping of the Spatial Organization of a Bacterial Chromosome

Open access
Le, Tung B. K., Imakaev, Maxim V., Mirny, Leonid A., Laub, Michael T.·2013·Science

Abstract

Caulobacter Chromosome: Chromosomal DNA must be highly compacted to fit within the tiny volume of the cell, while at the same time it must maintain a conformation that allows critical cellular processes access to the genome. Le et al. (p. 731 , published online 24 October) analyzed the structure of the circular chromosome in the prokaryote Caulobacter crescentus by using chromosome conformation capture and deep-sequencing. Highly self-interacting regions (chromosomal interaction domains, or CIDs) were observed—similar to the topologically associated domains previously seen in eukaryotes. Supercoiling helped to establish CIDs, and CID boundaries were defined by highly expressed genes. CIDs appeared to be established during or shortly after DNA replication, and could potentially facilitate chromosomal segregation by preventing newly replicated chromosomes from becoming entangled.

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Metadata

Authors
Le, T. B. K., Imakaev, M. V., Mirny, L. A., & Laub, M. T.
Venue
Science
Published
2013-11-08
Volume
342
Issue
6159
Pages
731-734
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2009653511
Cited by
604
References
5
FWCI
18.02
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: High-Resolution Mapping of the Spatial Organization of a Bacterial Chromosome. https://app.cochat.ai/papers/10.1126/science.1242059
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Le, T. B. K., Imakaev, M. V., Mirny, L. A., & Laub, M. T. (2013). High-Resolution Mapping of the Spatial Organization of a Bacterial Chromosome. Science. https://doi.org/10.1126/science.1242059

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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