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Cited by 1,171Genomics and Chromatin DynamicsChromatin Remodeling and CancerNuclear Structure and Function

Organizational principles of 3D genome architecture

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Rowley, M. Jordan, Corces, Victor G.·2018·Nature Reviews Genetics
DOI 10.1038/s41576-018-0060-8PMC PMC6312108
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Abstract

Studies of 3D chromatin organization have suggested that chromosomes are hierarchically organized into large compartments composed of smaller domains called topologically associating domains (TADs). Recent evidence suggests that compartments are smaller than previously thought and that the transcriptional or chromatin state is responsible for interactions leading to the formation of small compartmental domains in all organisms. In vertebrates, CTCF forms loop domains, probably via an extrusion process involving cohesin. CTCF loops cooperate with compartmental domains to establish the 3D organization of the genome. The continuous extrusion of the chromatin fibre by cohesin may also be responsible for the establishment of enhancer-promoter interactions and stochastic aspects of the transcription process. These observations suggest that the 3D organization of the genome is an emergent property of chromatin and its components, and thus may not be only a determinant but also a consequence of its function.

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  • It has been proposed that Drosophila TADs are formed by condensation of nucleosomes and thus should be rather called 'compartmental domains'.

    “It has been proposed that Drosophila TADs are formed by condensation of nucleosomes [123] and thus should be rather called “compartmental domains” [124].”

    From Enhancer Function in the 3D Genome (2023) · cites this paper as [124]

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Cited by

Sorted by citations

Authors
Rowley, M. J., & Corces, V. G.
Affiliations
Emory University (US)
Corresponding author
Corces, Victor G.
ORCID
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2018-10-26
Volume
19
Issue
12
Pages
789-800
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
DOI
10.1038/s41576-018-0060-8
PMC
PMC6312108
OpenAlex
W2898577086
Cited by
1,171
References
26
Citations by year
2026: 135 · 2025: 158 · 2024: 137 · 2023: 141 · 2022: 158 · 2021: 176 · 2020: 151 · 2019: 111 · 2018: 3 · 2014: 1
FWCI
11.52
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (K99GM127671, R00GM127671, R01GM035463)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
3D genome organization, topologically associating domains, CTCF, cohesin, chromatin looping, enhancer-promoter interactions, chromatin structure, transcriptional regulation, chromosome conformation
MeSH terms
Animals, Chromatin, Enhancer Elements, Genetic, Humans, Promoter Regions, Genetic, Genome, Human, Chromatin Assembly and Disassembly

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