Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning

Bae, Byoung-Il, Tietjen, Ian, Atabay, Kutay D., Evrony, Gilad D., Johnson, Matthew B., Asare, Ebenezer, Wang, Peter P., Murayama, Ayako Y., Im, Kiho, Lisgo, Steven N., Overman, Lynne, Šestan, Nenad, Chang, Bernard S., Barkovich, A. James, Grant, P. Ellen, Topçu, Meral, Politsky, Jeffrey, Okano, Hideyuki, Piao, Xianhua, Walsh, Christopher A.·2014·Science
DOI 10.1126/science.1244392

Cited by (237)

Items 101–200 of 237

  1. An interaction network of mental disorder proteins in neural stem cells
    Maaike J. Moen, Hieab H.H. Adams, Johannes H. Brandsma, Dick H. W. Dekkers, Umut Akinci, Sofia Karkampouna, Martí Quevedo, Christel E. M. Kockx, Zeliha Özgür, Wilfred F. J. van IJcken et al. · 2017 · Translational Psychiatry
  2. GPR56: An adhesion GPCR involved in brain development, neurological disorders and cancer
    Raksha A. Ganesh, Krishnan Venkataraman, Ravi Sirdeshmukh · 2020 · Brain Research
  3. H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion
    Cemil Kerimoglu, Linh Pham, Anton B. Tonchev, M. Sadman Sakib, Yuanbin Xie, Godwin Sokpor, Pauline Antonie Ulmke, Lalit Kaurani, Eman Abbas, Huong Nguyen et al. · 2021 · Science Advances
  4. Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8
    Jian‐Yun Nie, Chao Xu, Jing Jin et al. · 2015 · Structure
  5. Transcriptomic profile analysis of mouse neural tube development by RNA‐Seq
    Juan Yu, Jianbing Mu, Qian Guo, Lihong Yang, Juan Zhang, Zhizhen Liu, Baofeng Yu, Ting Zhang, Jun Xie · 2017 · IUBMB Life
  6. Roots of the Malformations of Cortical Development in the Cell Biology of Neural Progenitor Cells
    Chiara Ossola, Nereo Kalebic · 2022 · Frontiers in Neuroscience
  7. Epilepsy and malformations of cortical development.
    2003 · PubMed
  8. Periostin, a neurite outgrowth‐promoting factor, is expressed at high levels in the primate cerebral cortex
    Eiji Matsunaga, Sanae Nambu, Mariko Oka, Michio Tanaka, Miki Taoka, Atsushi Iriki · 2015 · Development Growth & Differentiation
  9. Versatile Signaling Activity of Adhesion GPCRs
    Ayush Kishore, Randy A. Hall · 2016 · Handbook of experimental pharmacology
  10. Genome sequencing in families with congenital limb malformations
    Jonas Elsner, Martin A. Mensah, Manuel Holtgrewe, Jakob Hertzberg, Stefania Bigoni, Andreas Busche, Marie Coutelier, Deepthi C. de Silva, Nursel H Elcioglu, Isabel Filges et al. · 2021 · Human Genetics
  11. The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors
    Rory K. Morgan, Garret R. Anderson, Demet Araç, Gabriela Aust, Nariman Aghaei Bandbon Balenga, Antony A. Boucard, James P. Bridges, Felix Benedikt Engel, Caroline J. Formstone, Maike D. Glitsch et al. · 2019 · Annals of the New York Academy of Sciences
  12. Novel gene function and regulation in neocortex expansion
    Michael Heide, Katherine R. Long, Wieland Β. Huttner · 2017 · Current Opinion in Cell Biology
  13. Mapping arealisation of the visual cortex of non-primate species: lessons for development and evolution
    Jihane Homman‐Ludiye · 2014 · Frontiers in Neural Circuits
  14. Evolutionary Changes in Transcriptional Regulation: Insights into Human Behavior and Neurological Conditions
    Ryan N. Doan, Taehwan Shin, Christopher A. Walsh · 2018 · Annual Review of Neuroscience
  15. Molecular drivers of human cerebral cortical evolution
    Ikuo Suzuki · 2019 · Neuroscience Research
  16. CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia
    Lixiazi He, Christian Arnold, Judith Thoma, Christian Rohde, Maksim M. Kholmatov, Swati Garg, Cheng‐Chih Hsiao, Linda Viol, Kaiqing Zhang, Rui Sun et al. · 2022 · EMBO Molecular Medicine
  17. Functions of G protein‐coupled receptor 56 in health and disease
    Tiantian Su, Qiuyun Guan, Huijuan Cheng, Zhenduo Zhu, Chunru Jiang, Paipai Guo, Yu Tai, Hanfei Sun, Manman Wang, Wei Wei et al. · 2022 · Acta Physiologica
  18. Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
    Katia K. Mattis, Nicole A. J. Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Han Sun, Jennifer M. Iklé, Swaraj Thaman, Antje K. Rottner, Austin Bautista et al. · 2023 · Diabetologia
  19. Human SERPINA3 induces neocortical folding and improves cognitive ability in mice
    Jinyue Zhao, Chao Feng, Wenwen Wang, Libo Su, Jianwei Jiao · 2022 · Cell Discovery
  20. The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex
    Paula Cubillos, Nora Ditzer, Annika Kolodziejczyk, Gustav Schwenk, Janine Hoffmann, Theresa M. Schütze, Răzvan Petru Derihaci, Cahit Birdir, Johannes E. M. Köllner, Andreas Petzold et al. · 2024 · The EMBO Journal
  21. Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function
    Szymon P. Kordon, Kristína Cechová, Sumit J. Bandekar, Katherine Leon, Przemysław Dutka, Gracie Siffer, Anthony A. Kossiakoff, Reza Vafabakhsh, Demet Araç · 2024 · Nature Communications
  22. Heterogeneous nuclear ribonucleoprotein A3a controls mitotic progression of neural progenitors via interaction with cohesin
    Min‐Yi Ou, Xiang-Chun Ju, Yi-Jun Cai, Xin-Yao Sun, Junfeng Wang, Xiu-Qing Fu, Qiang Sun, Zhen‐Ge Luo · 2020 · Development
  23. No Country for Oldowan Men: Emerging Factors in Language Evolution
    Elliot Murphy · 2019 · Frontiers in Psychology
  24. Inheritance and flexibility of cell polarity: a clue for understanding human brain development and evolution
    Nereo Kalebic, Takashi Namba · 2021 · Development
  25. Adhesion G‐protein coupled receptor 56 is required for 3T3‐L1 adipogenesis
    Mohammad Al Hasan, Poornima Roy, Sharron Dolan, Patricia E. Martin, Steven Patterson, Chris Bartholomew · 2019 · Journal of Cellular Physiology
  26. The adhesion G protein‐coupled receptor GPR56/ADGRG1 in cytotoxic lymphocytes
    Cheng‐Chih Hsiao, Els Vos, Klaas P. J. M. van Gisbergen, Jörg Hamann · 2023 · Basic & Clinical Pharmacology & Toxicology
  27. New Technologies for Monitoring Marine Mammal Health
    Annalaura Mancia · 2018 · Elsevier eBooks
  28. Solving the unsolved genetic epilepsies: Current and future perspectives
    Katrine M. Johannesen, Zeynep Tümer, Sarah Weckhuysen, Tahsin Stefan Barakat, Allan Bayat · 2023 · Epilepsia
  29. CWAS-Plus: estimating category-wide association of rare noncoding variation from whole-genome sequencing data with cell-type-specific functional data
    Yujin Kim, Minwoo Jeong, In Gyeong Koh, Chanhee Kim, Hyeji Lee, Jae Hyun Kim, Ronald Yurko, Il Bin Kim, Jeongbin Park, Donna M. Werling et al. · 2024 · Briefings in Bioinformatics
  30. Age‐related changes of sulcal imprints on the endocranium in the Japanese macaque (Macaca fuscata)
    Nguyễn Văn Minh, Yuzuru Hamada · 2017 · American Journal of Physical Anthropology
  31. Novel Kidins220/ARMS Splice Isoforms: Potential Specific Regulators of Neuronal and Cardiovascular Development
    Nathalie Schmieg, Claire Thomas, Arisa Yabe, David S. Lynch, Teresa Iglesias, Probir Chakravarty, Giampietro Schiavo · 2015 · PLoS ONE
  32. Structure, function and therapeutic potential of adhesion GPCRs
    Demet Araç, Katherine Leon · 2019 · Elsevier eBooks
  33. An Atypical Sulcal Pattern in Children with Disorders of the Corpus Callosum and Its Relation to Behavioral Outcomes
    Lana Vasung, Hyuk Jin Yun, Henry A. Feldman, Patricia Ellen Grant, Kiho Im · 2020 · Cerebral Cortex
  34. The polymicrogyria-associated GPR56 promoter preferentially drives gene expression in developing GABAergic neurons in common marmosets
    Ayako Y. Murayama, Ken-ichiro Kuwako, Junko Okahara, Byoung-Il Bae, Misako Okuno, Hiromi Mashiko, Tomomi Shimogori, Christopher A. Walsh, Erika Sasaki, Hideyuki Okano · 2020 · Scientific Reports
  35. Adhesion GPCR GPR56 Expression Profiling in Human Tissues
    Fyn Kaiser, Markus Morawski, Knut Krohn, Nada Rayes, Cheng‐Chih Hsiao, Marianne Quaas, Gabriela Aust · 2021 · Cells
  36. Rbfox1 Is Expressed in the Mouse Brain in the Form of Multiple Transcript Variants and Contains Functional E Boxes in Its Alternative Promoters
    Sonia Casanovas, Laura Schlichtholz, Sophia Mühlbauer, Sri Dewi, Martin Schüle, Dennis J. Strand, Susanne Strand, Lea Zografidou, Jennifer Winter · 2020 · Frontiers in Molecular Neuroscience
  37. The repertoire and structure of adhesion GPCR transcript variants assembled from publicly available deep-sequenced human samples
    Christina Katharina Kuhn, Udo Stenzel, Sandra Berndt · 2024 · Nucleic Acids Research
  38. Human NDE1 splicing and mammalian brain development
    Sarah Mosca, Michela Raponi, Anna Meneghello, Emanuele Buratti, Christopher Geoffrey Woods, Diana Baralle · 2017 · Scientific Reports
  39. Genetic Resolutions of Brain Convolutions
    Brian G. Rash, PASKO T. RAKIC · 2014 · Science
  40. GPR56 S4 variant is required for microglia‐mediated synaptic pruning
    Tao Li, Rong Luo, Rachael Schmidt, Nicholas D'Alessandro, Priya Kishore, Beika Zhu, Diankun Yu, Xianhua Piao · 2022 · Glia
  41. The Clinical Picture of a Bilateral Perisylvian Syndrome as the Initial Symptom of Mega-Corpus-Callosum Syndrome due to a MAST1-Gene Mutation
    Laura Hecher, Jessika Johannsen, Tatjana Bierhals · 2020 · Neuropediatrics
  42. GNG5 Controls the Number of Apical and Basal Progenitors and Alters Neuronal Migration During Cortical Development
    Ane Cristina Ayo-Martin, Christina Kyrousi, Rossella Di Giaimo, Silvia Cappello · 2020 · Frontiers in Molecular Biosciences
  43. Gene Expression Profiling in Huntington’s Disease: Does Comorbidity with Depressive Symptoms Matter?
    Gabriela Delevati Colpo, Natália Pessoa Rocha, Erin E. Furr-Stimming, Antônio Lúcio Teixeira · 2020 · International Journal of Molecular Sciences
  44. GPR56 homozygous nonsense mutation p.R271* associated with phenotypic variability in bilateral frontoparietal polymicrogyria
    Tülay Öncü Öner, Aycan Ünalp, İlknur Porsuk-Doru · 2018 · The Turkish Journal of Pediatrics
  45. The Genetic Landscape of Polymicrogyria
    Jesmy James, Mary Iype, Mithran Omana Surendran, Ayyappan Anitha, Sanjeev V. Thomas · 2022 · Annals of Indian Academy of Neurology
  46. GPR56: A potential therapeutic target for neurological and psychiatric disorders
    Wang Qi, Wei Guan · 2024 · Biochemical Pharmacology
  47. The Evolving Landscape of Functional Models of Autism Spectrum Disorder
    Jai Ranjan, Aniket Bhattacharya · 2025 · Cells
  48. Adhesion G protein-coupled receptors
    Tobias Langenhan, Garret R. Anderson, Demet Araç, Gabriela Aust, Monserrat Avila-Zozaya, Sofie Morsing Bagger, Patrick Barth, Sandra Berndt, Stephen C. Blacklow, Beatriz Blanco-Redondo et al. · 2026 · Pharmacological Reviews
  49. Human Brain Biochemistry
    Omar S. Hajjawi · 2014 · American Journal of BioScience
  50. Introduction: History of the Adhesion GPCR Field
    Jörg Hamann, Alexander G. Petrenko · 2016 · Handbook of experimental pharmacology
  51. Family-based whole-genome sequencing identifies compound heterozygous protein-coding and noncoding mutations in tetralogy of Fallot
    Yifeng Wang, Tao Jiang, Pushi Tang, Yifei Wu, Zhu Jiang, Juncheng Dai, Yayun Gu, Jing Xu, Min Da, Hongxia Ma et al. · 2020 · Gene
  52. Nitric oxide signaling in the development and evolution of language and cognitive circuits
    Owen H. Funk, Kenneth Y. Kwan · 2014 · Neuroscience Research
  53. Fractal analysis of brain shape formation predicts age and genetic similarity in human newborns
    Stephan Krohn, Amy Romanello, Nina von Schwanenflug, Jerod M. Rasmussen, Claudia Buß, Sofie Louise Valk, Christopher R. Madan, Carsten Finke · 2025 · Nature Neuroscience
  54. Genomic approaches to trace the history of human brain evolution with an emerging opportunity for transposon profiling of ancient humans
    Yilan Wang, Boxun Zhao, Jaejoon Choi, Eunjung Alice Lee · 2021 · Mobile DNA
  55. Genetics of human brain evolution
    Eric J. Vallender · 2019 · Progress in brain research
  56. Characterizing sensitivity and coverage of clinical WGS as a diagnostic test for genetic disorders
    Yan Sun, Fengxia Liu, Chunna Fan et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Rare variation in noncoding regions with evolutionary signatures contributes to autism spectrum disorder risk
    Taehwan Shin, Janet H. T. Song, Michael Kosicki et al. · 2023 · medRxiv
  58. Association between placental oxygen transport and fetal brain cortical development: a study in monochorionic diamniotic twins
    Esra Abacı Türk, Hyuk Jin Yun, Henry A. Feldman, Joo Young Lee, Hyun Ju Lee, Carolina Bibbo, Cindy Zhou, Rubii M. Tamen, Patricia Ellen Grant, Kiho Im · 2023 · Cerebral Cortex
  59. High‐throughput RNA sequencing reveals structural differences of orthologous brain‐expressed genes between western lowland gorillas and humans
    Leonard Lipovich, Zhuo-Cheng Hou, Hui Jia, Christopher A. Sinkler, Michael R. McGowen, Kirstin N. Sterner, Amy L. Weckle, Amara Brighe Sugalski, Lenore Pipes, Domenico L. Gatti et al. · 2015 · The Journal of Comparative Neurology
  60. The Comparative Neurology of Neocortical Gyration and the Quest for Functional Specialization
    Lazaros C. Triarhou · 2017 · Frontiers in Systems Neuroscience
  61. A Human Accelerated Region participates in early human forebrain patterning and expansion
    Sandra Acosta, Jaydeep Sidhaye, Luciano Fiore, Isabel Rollán, Giovanni Iacono, Alexander V. Misharin, Nozomu Takata, Martin Sikora, Nikita Joshi, Beisi Xu et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  62. Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains
    Szymon P. Kordon, Kristína Cechová, Sumit J. Bandekar, Katherine Leon, Przemysław Dutka, Gracie Siffer, Anthony A. Kossiakoff, Reza Vafabakhsh, Demet Araç · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  63. Modularization of adhesion G protein-coupled receptor (aGPCR) structure: how alternative splicing regulates synaptogenesis
    Tobias Langenhan · 2024 · Signal Transduction and Targeted Therapy
  64. The Economic Impact of Medication-Resistant Epilepsy
    Charles E. Begley, Shin Jeong · 2020 · Cambridge University Press eBooks
  65. Noncoding Variants Functional Prioritization Methods Based on Predicted Regulatory Factor Binding Sites
    Haoyue Fu, Lianping Yang, Xiangde Zhang · 2017 · Current Genomics
  66. Malformations of Cortical Development, Cognitive Involvementand Epilepsy: A Single Institution Experience in 19 Young Patients
    Valeria Venti, Maria Chiara Consentino, Pierluigi Smilari, Filippo Greco, Claudia Francesca Oliva, Agata Fiumara, Raffaele Falsaperla, Martino Ruggieri, Piero Pavone · 2021 · Children
  67. Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
    Katia K. Mattis, Nicole A. J. Krentz, Christoph Metzendorf et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  68. A specific GPR56/ADGRG1 splicing isoform is associated with antidepressant response in major depressive disorder
    Montaine Lion, El Chérif Ibrahim, Elodie Caccomo-Garcia, Julie Bourret, Guillaume Cinquanta, Olfa Khalfallah, Nicolas Glaichenhaus, Laëtitia Davidovic, Philippe Courtet, Gustavo Turecki et al. · 2025 · European Neuropsychopharmacology
  69. Two Novel Compound Heterozygous ADGRG1/GPR56 Mutations Associated with Diffuse Cerebral Polymicrogyria
    Ruchika Jha, Uday Bhanu Kovilapu, Amit Devgan · 2020 · Journal of Pediatric Genetics
  70. Medication-Resistant Epilepsy in Adults
    Martin Holtkamp, Felix Benninger · 2020 · Cambridge University Press eBooks
  71. Molecular Evolution and Phenotypic Change
    Eric J. Vallender · 2016 · Elsevier eBooks
  72. Cortical sulci in the human fetal brain and development
    Kiho Im · 2021 · Elsevier eBooks
  73. Pharmacotherapy for Medication-Resistant Epilepsy
    Graham A. Powell, Anthony Guy Marson · 2020 · Cambridge University Press eBooks
  74. Frequently Asked Questions for: The Atoms of Neural Computation
    Gary Marcus, Adam Henry Marblestone, Tom Dean · 2014 · bioRxiv (Cold Spring Harbor Laboratory)
  75. Anti-GPR56 monoclonal antibody potentiates GPR56-mediated Src-Fak signaling to modulate cell adhesion
    Treena Chatterjee, Sheng Zhang, Tressie A. Posey · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  76. Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
    Szymon P. Kordon, Przemysław Dutka, Justyna M. Adamska · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  77. CWAS-Plus: Estimating category-wide association of rare noncoding variation from whole-genome sequencing data with cell-type-specific functional data
    Yu‐Jin Kim, Minwoo Jeong, In Gyeong Koh et al. · 2024 · medRxiv
  78. Morphogenesis and morphometry of brain folding patterns across species
    Sifan Yin, Chunzi Liu, Gary P. T. Choi · 2025 · eLife
  79. Gene regulatory networks controlling neuronal development
    Jason T. Lambert, J.L. Haigh, Alex S. Nord · 2020 · Elsevier eBooks
  80. Psychiatric Comorbidities in Medication-Resistant Epilepsy
    Andres Miguel Kanner · 2020 · Cambridge University Press eBooks
  81. Medication-Resistant Epilepsy Syndromes in Children
    Elia Pestana‐Knight, Elaine Wyllie · 2020 · Cambridge University Press eBooks
  82. Linking adhesion GPCRs to glial cell development and function
    Brian Chiou, Xianhua Piao · 2021 · Elsevier eBooks
  83. A historical and technological perspective on the evolution of the human brain transcriptome
    Ryan D. Risgaard, Hannah M. Doll, André M. M. Sousa · 2025 · Elsevier eBooks
  84. Morphogenesis and morphometry of brain folding patterns across species
    Sifan Yin, Chunzi Liu, Gary PT Choi · 2025 · eLife
  85. Basal progenitors as drivers of neocortical expansion
    Soraia Barão, Ulrich Müller · 2026 · Trends in Neurosciences
  86. The EJC component Magoh in non-vertebrate chordates
    Rosa Maria Sepe, Jung Hee Levialdi Ghiron, Ivana Zucchetti, Luigi Caputi, Raffaella Tarallo, Fabio Crocetta, Rosaria De Santis, Salvatore D’Aniello, Paolo Sordino · 2020 · Development Genes and Evolution
  87. Social Consequences of Medication-Resistant Epilepsy
    Amy Z. Crepeau, Joseph I Sirven · 2020 · Cambridge University Press eBooks
  88. Medication-Resistant Epilepsy
    2020 · Cambridge University Press eBooks
  89. Neuronal Migration
    Alissa M. D’Gama, Annapurna Poduri, Joseph J. Volpe · 2024 · Elsevier eBooks
  90. [Screening and validation of long non-coding RNAs in brain tissue of inflammation-induced preterm mice].
    Rujuan Chen, Sha Xi, Fan Wang, Mi Xiao, Xiaojie Lin, Li Liu · 2016 · PubMed Central
  91. The Natural History of Epilepsy
    Byungin Lee, Sung‐Eun Kim · 2020 · Cambridge University Press eBooks
  92. H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion by activating TRNP1 expression
    Cemil Kerimoglu, Linh Pham, Anton B. Tonchev et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  93. Morphogenesis and morphometry of brain folding patterns across species
    Sifan Yin, Chunzi Liu, Gary P. T. Choi · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  94. Morphogenesis and morphometry of brain folding patterns across species
    Sifan Yin, Chunzi Liu, Gary P. T. Choi · 2025 · eLife
  95. Morphogenesis and morphometry of brain folding patterns across species
    Sifan Yin, Chunzi Liu, Gary P. T. Choi · 2025 · eLife
  96. A Mathematical Framework of Human Thought Process: Rectifying Software Construction Inefficiency and Identifying Characteristic Efficiencies of Networked Systems Via Problem-solution Cycle
    Jonathan Sarbah-Yalley · 2015 · Digital Commons - Andrews University (Andrews University)
  97. The Cell Biology of Neural Stem and Progenitor Cells and Neocortex Expansion in Development and Evolution
    Stefania Tavano, Wieland Β. Huttner · 2017 · Elsevier eBooks
  98. A Small Pure 3q25.1 Duplication Associated with Multiple Cerebral Organizational Defects
    Jesús David Sendoya Vargas · 2018 · International Journal of Genetics and Genomics
  99. Approach to the Treatment of Medication-Resistant Epilepsy
    John M. Stern · 2020 · Cambridge University Press eBooks
  100. Hippocampal Sclerosis as a Cause of Medication-Resistant Epilepsy
    Fahmida A Chowdhury, Beate Diehl, Maria Thom · 2020 · Cambridge University Press eBooks