Okano, Hideyuki

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature

Autophagy in Disease and TherapyGenetic Neurodegenerative Diseases

Cited by 3,882

Generation of transgenic non-human primates with germline transmission

Sasaki, E., Suemizu, H., Shimada, A., Hanazawa, K., Oiwa, R., Kamioka, M., Tomioka, I., Sotomaru, Y., Hirakawa, R., Eto, T., et al. (2009) · Nature

Animal Genetics and ReproductionVirus-based gene therapy research

Cited by 712

Modeling familial Alzheimer's disease with induced pluripotent stem cells

Yagi, T., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Yoshizaki, T., Yamanaka, S., Okano, H., & Suzuki, N. (2011) · Human Molecular Genetics

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 599

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Fujimori, K., Ishikawa, M., Otomo, A., Atsuta, N., Nakamura, R., Akiyama, T., Hadano, S., Aoki, M., Saya, H., Sobue, G., et al. (2018) · Nature Medicine

Amyotrophic Lateral Sclerosis ResearchPluripotent Stem Cells Research

Cited by 494

Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor

Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., et al. (1996) · Nature

Ion channel regulation and functionEpilepsy research and treatment

Cited by 485

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

Hashimoto, K., Kouno, T., Ikawa, T., Hayatsu, N., Miyajima, Y., Yabukami, H., Terooatea, T., Sasaki, T., Suzuki, T., Valentine, M., et al. (2019) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologySingle-cell and spatial transcriptomics

Cited by 343

The bHLH Gene Hes1 as a Repressor of the Neuronal Commitment of CNS Stem Cells

Nakamura, Y., Sakakibara, S.-I., Miyata, T., Ogawa, M., Shimazaki, T., Weiss, S., Kageyama, R., & Okano, H. (2000) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 316

Pre-Evaluated Safe Human iPSC-Derived Neural Stem Cells Promote Functional Recovery after Spinal Cord Injury in Common Marmoset without Tumorigenicity

Kobayashi, Y., Okada, Y., Itakura, G., Iwai, H., Nishimura, S., Yasuda, A., Nori, S., Hikishima, K., Konomi, T., Fujiyoshi, K., et al. (2012) · PLoS ONE

Spinal Cord Injury ResearchNerve injury and regeneration

Cited by 315

Stem cell-like properties of the endometrial side population: implication in endometrial regeneration

Masuda, H., Matsuzaki, Y., Hiratsu, E., Ono, M., Nagashima, T., Kajitani, T., Arase, T., Oda, H., Uchida, H., Asada, H., et al. (2010) · PLoS ONE

Mesenchymal stem cell researchCancer Cells and Metastasis

Cited by 303

WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans

Rocheleau, C. E., Yasuda, J., Shin, T. H., Lin, R., Sawa, H., Okano, H., Priess, J. R., Davis, R. J., & Mello, C. C. (1999) · Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 276

Bone marrow–derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice

Higashiyama, R., Inagaki, Y., Hong, Y. Y., Kushida, M., Nakao, S., Niioka, M., Watanabe, T., Okano, H., Matsuzaki, Y., Shiota, G., et al. (2007) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 261

Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development

Naka, H., Nakamura, S., Shimazaki, T., & Okano, H. (2008) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 243

Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning

Bae, B.-I., Tietjen, I., Atabay, K. D., Evrony, G. D., Johnson, M. B., Asare, E., Wang, P. P., Murayama, A. Y., Im, K., Lisgo, S. N., et al. (2014) · Science

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 229

The RNA-binding protein HuD regulates neuronal cell identity and maturation

Akamatsu, W., Fujihara, H., Mitsuhashi, T., Yano, M., Shibata, S., Hayakawa, Y., Okano, H. J., Sakakibara, S.-I., Takano, H., Takano, T., et al. (2005) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 222

Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells

Nakamura, M., & Okano, H. (2013) · Cell Research

Pluripotent Stem Cells ResearchSpinal Cord Injury Research

Cited by 214

New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain

Kaneko, N., Marín, O., Koike, M., Hirota, Y., Uchiyama, Y., Wu, J. Y., Lu, Q., Tessier-Lavigne, M., Alvarez-Buylla, A., Okano, H., et al. (2010) · Neuron

Neurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

Cited by 212

Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability

Ince-Dunn, G., Okano, H. J., Jensen, K. B., Park, W.-Y., Zhong, R., Ule, J., Mele, A., Fak, J. J., Yang, C., Zhang, C., et al. (2012) · Neuron

RNA Research and SplicingNeuroscience and Neuropharmacology Research

Cited by 212

Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb

Kaneko, N., Okano, H., & Sawamoto, K. (2006) · Genes to Cells

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 202

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., Yamashita, K., Shigaki, S., Ono, T., Yukioka, H., et al. (2020) · Endocrine Journal

Sirtuins and Resveratrol in MedicineFolate and B Vitamins Research

Cited by 191

Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing

Sato, K., Oiwa, R., Kumita, W., Henry, R., Sakuma, T., Ito, R., Nozu, R., Inoue, T., Katano, I., Sato, K., et al. (2016) · Cell Stem Cell

CRISPR and Genetic EngineeringAnimal Genetics and Reproduction

Cited by 159

Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

Hirata, T., Arai, Y., Yuasa, S., Abe, Y., Takayama, M., Sasaki, T., Kunitomi, A., Inagaki, H., Endo, M., Morinaga, J., et al. (2020) · Nature Communications

Genetics, Aging, and Longevity in Model OrganismsFrailty in Older Adults

Cited by 138

Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss

Fujioka, M., Okano, H., & Ogawa, K. (2014) · Frontiers in Pharmacology

Hearing, Cochlea, Tinnitus, GeneticsVestibular and auditory disorders

Cited by 134

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

Tanaka, H., Homma, H., Fujita, K., Kondo, K., Yamada, S., Jin, X., Waragai, M., Ohtomo, G., Iwata, A., Tagawa, K., et al. (2020) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 119

Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives

Itakura, G., Kawabata, S., Ando, M., Nishiyama, Y., Sugai, K., Ozaki, M., Iida, T., Ookubo, T., Kojima, K., Kashiwagi, R., et al. (2017) · Stem Cell Reports

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 115