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Optical Control of Muscle Function by Transplantation of Stem Cell–Derived Motor Neurons in Mice
Open accessAbstract
Optogenetics Applied to Motorneuron Control: Nerves damaged by disease or injury do not always regenerate. In such cases, therapies involving transplanted stem cells show some promise. However, the new neurons derived from transplanted cells cannot communicate with the central control systems that would normally regulate movement. To avoid the need for such communication, in a proof-of-principle study, Bryson et al. (p. 94 ; see the Perspective by Iyer and Delp ) added optogenetic control to differentiation and transplantation of motor neurons. In the mouse, these engineered neurons were able to reestablish connections within a damaged sciatic nerve and, when activated by localized light stimulation, could drive muscle contractions.
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“The results demonstrated that regenerative medicine and optic stimulation can be used together to reinnervate peripheral nerves [134].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [134]
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Metadata
- Authors
- Bryson, J. B., Machado, C. B., Crossley, M., Stevenson, D., Bros-Facer, V., Burrone, J., Greensmith, L., & Lieberam, I.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Guy's Hospital (GB)
- Sobell Department of Motor Neuroscience and Movement Disorders, University College London (UCL) Institute of Neurology, London, UK.
- Corresponding author
- Machado, Carolina Barcellos
- Crossley, Martin
- Stevenson, Danielle
- Greensmith, Linda
- Lieberam, Ivo
- Venue
- Science
- Published
- 2014-04-04
- Volume
- 344
- Issue
- 6179
- Pages
- 94-97
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5947756
- OpenAlex
- W2055697048
- Cited by
- 163
- References
- 27
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 3 · 2023: 10 · 2022: 14 · 2021: 13 · 2020: 10 · 2019: 14 · 2018: 14 · 2017: 18 · 2016: 26 · 2015: 17 · 2014: 12
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust (095589)
- Medical Research Council (MR/K000608/1)
- Biotechnology and Biological Sciences Research Council (G1001234)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- optogenetics, channelrhodopsin-2, central nervous system injury, regenerative medicine
- MeSH terms
- Channelrhodopsins, Animals, Axons, Cell Line, Electric Stimulation, Female, Hindlimb, Isometric Contraction, Light, Mice, Inbred C57BL, Motor Neurons, Muscle Denervation, Nerve Regeneration, Sciatic Nerve, Transfection, Muscle, Skeletal, Muscle Fibers, Skeletal, Transgenes, Mice, Embryonic Stem Cells, Optogenetics
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