Optical Control of Muscle Function by Transplantation of Stem Cell–Derived Motor Neurons in Mice

Efficient selection for high-expression transfectants with a novel eukaryotic vector

Niwa, H., Yamamura, K., & Miyazaki, J. (1991) · Gene · doi:10.1016/0378-1119(91)90434-d · Cited by 5,149

Millisecond-timescale, genetically targeted optical control of neural activity

Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 5,015

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

Nagel, G., Szellas, T., Huhn, W., Kateriya, S., Adeishvili, N., Berthold, P. R., Ollig, D., Hegemann, P., & Bamberg, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1936192100 · Cited by 2,730

Directed differentiation of embryonic stem cells into motor neurons.

Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,792

Relation between size of neurons and their susceptibility to discharge

Henneman, E. (1957) · Science · doi:10.1126/science.126.3287.1345 · Cited by 1,227

Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS

Filbin, M. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1195 · Cited by 873

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation

Lin, J. Y., Knutsen, P. M., Muller, A., Kleinfeld, D., & Tsien, R. Y. (2013) · Nature Neuroscience · doi:10.1038/nn.3502 · Cited by 858

GFAP promoter directs astrocyte-specific expression in transgenic mice

Brenner, M., Kisseberth, W., Su, Y., Besnard, F., & Messing, A. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01030.1994 · Cited by 485

A Generic Intron Increases Gene Expression in Transgenic Mice

Choi, T., Huang, M. T. F., Gorman, C., & Jaenisch, R. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.6.3070 · Cited by 356

Activation of flavin-containing oxidases underlies light-induced production of H 2 O 2 in mammalian cells

Hockberger, P. E., Skimina, T. A., Centonze, V. E., Lavin, C., Chu, S., Dadras, S. S., Reddy, J. K., & White, J. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6255 · Cited by 320

Stretchable organic optoelectronic sensorimotor synapse

Lee, Y., Oh, J. Y., Xu, W., Kim, O., Kim, T. R., Kang, J., Kim, Y., Son, D., Tok, J. B. ‐., Park, M. J., et al. (2018) · Science Advances · doi:10.1126/sciadv.aat7387 · Cited by 542

Electrospinning: An enabling nanotechnology platform for drug delivery and regenerative medicine

Chen, S., Li, R., Li, X., & Xie, J. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.05.001 · Cited by 389

Optogenetic skeletal muscle-powered adaptive biological machines

Raman, R., Cvetkovic, C., Uzel, S. G. M., Platt, R. J., Sengupta, P., Kamm, R. D., & Bashir, R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516139113 · Cited by 347

Modeling ALS with motor neurons derived from human induced pluripotent stem cells

Sances, S., Bruijn, L. I., Chandran, S., Eggan, K., Ho, R., Klim, J. R., Livesey, M. R., Lowry, E., Macklis, J. D., Rushton, D., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4273 · Cited by 289

Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units

Uzel, S. G. M., Platt, R. J., Subramanian, V., Pearl, T. M., Rowlands, C. J., Chan, V., Boyer, L. A., So, P. T. C., & Kamm, R. D. (2016) · Science Advances · doi:10.1126/sciadv.1501429 · Cited by 212

Neuromodulation in the restoration of function after spinal cord injury

James, N. D., McMahon, S. B., Field-Fote, E. C., & Bradbury, E. J. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30287-4 · Cited by 192

Towards translational optogenetics

Bansal, A., Shikha, S., & Zhang, Y. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00829-3 · Cited by 174

In Vitro Microfluidic Models for Neurodegenerative Disorders

Osaki, T., Shin, Y., Sivathanu, V., Campisi, M., & Kamm, R. D. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700489 · Cited by 155

Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system

Montgomery, K. L., Iyer, S. M., Christensen, A. J., Deisseroth, K., & Delp, S. L. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7577 · Cited by 147

Optimal electrical stimulation boosts stem cell therapy in nerve regeneration

Du, J., Zhen, G., Chen, H. A., Zhang, S., Qing, L., Yang, X., Lee, G., Mao, H., & Jia, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.015 · Cited by 147

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Fairbairn, N. G. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i1.11 · Cited by 144

Moving Stem Cells to the Clinic: Potential and Limitations for Brain Repair

Steinbeck, J. A., & Studer, L. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.002 · Cited by 138

Optogenetic control of contractile function in skeletal muscle

Bruegmann, T., Bremen, T. V., Vogt, C. C., Send, T., Fleischmann, B. K., & Sasse, P. (2015) · Nature Communications · doi:10.1038/ncomms8153 · Cited by 133

A bioinspired optoelectronically engineered artificial neurorobotics device with sensorimotor functionalities

Akbari, M. K., & Zhuiykov, S. (2019) · Nature Communications · doi:10.1038/s41467-019-11823-4 · Cited by 133

Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease

Steinbeck, J. A., Jaiswal, M. K., Calder, E. L., Kishinevsky, S., Weishaupt, A., Toyka, K. V., Goldstein, P. A., & Studer, L. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.10.002 · Cited by 132

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

Yildiz, K. A., Shin, A. Y., & Kaufman, K. R. (2020) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-020-00667-5 · Cited by 113

Reactivation of Denervated Schwann Cells by Embryonic Spinal Cord Neurons to Promote Axon Regeneration and Remyelination

Fang, X., Zhang, C., Zhang, C., Cai, Y., Yu, Z., Huang, Z., Li, W., & Zhang, W. (2019) · Stem Cells International · doi:10.1155/2019/7378594 · Cited by 106

Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction

Gordon, D., Dafinca, R., Scaber, J., Alegre‐Abarrategui, J., Farrimond, L. E., Scott, C., Biggs, D., Kent, L., Oliver, P. L., Davies, B., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.024 · Cited by 94

Gold Nanoshell-Mediated Remote Myotube Activation

Marino, A., Arai, S., Hou, Y., Degl’Innocenti, A., Cappello, V., Mazzolai, B., Chang, Y., Mattoli, V., Suzuki, M., & Ciofani, G. (2017) · ACS Nano · doi:10.1021/acsnano.6b08202 · Cited by 88

Reconnecting Eye to Brain

Crair, M. C., & Mason, C. A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1711-16.2016 · Cited by 86

Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures

Lam, R. S., Töpfer, F. M., Wood, P. G., Busskamp, V., & Bamberg, E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169506 · Cited by 82

Optogenetic control of nerve growth

Park, S., Koppes, R. A., Froriep, U. P., Jia, X., Achyuta, A. K. H., McLaughlin, B. L., & Anikeeva, P. (2015) · Scientific Reports · doi:10.1038/srep09669 · Cited by 81

Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis

Ciervo, Y., Ning, K., Xu, J., Shaw, P. J., & Mead, R. J. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0227-3 · Cited by 83

The Evolution of Neuroprosthetic Interfaces

Adewole, D. O., Serruya, M. D., Harris, J. P., Burrell, J. C., Petrov, D., Chen, H.-C. I., Wolf, J. A., & Cullen, D. K. (2016) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.2016017198 · Cited by 86

Restoring nervous system structure and function using tissue engineered living scaffolds

Struzyna, L. A., Harris, J. P., Katiyar, K. S., Chen, H., & Cullen, D. K. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.156943 · Cited by 78

The Roles of Optogenetics and Technology in Neurobiology: A Review

Chen, W., Li, C., Liang, W., Li, Y., Zou, Z., Xie, Y., Liao, Y., Lin, Y., Lin, Q., Huang, M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.867863 · Cited by 71

Living scaffolds for neuroregeneration

Struzyna, L. A., Katiyar, K. S., & Cullen, D. K. (2014) · Current Opinion in Solid State and Materials Science · doi:10.1016/j.cossms.2014.07.004 · Cited by 75

Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells

Thompson, L. H., & Björklund, A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.003 · Cited by 68

Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

Izquierdo-Serra, M., Bautista-Barrufet, A., Trapero, A., Garrido‐Charles, A., Díaz‐Tahoces, A., Camarero, N., Pittolo, S., Valbuena, S., Perez‐Jiménez, A., Gay, M., et al. (2016) · Nature Communications · doi:10.1038/ncomms12221 · Cited by 67

Optogenetics in bacteria – applications and opportunities

Lindner, F., & Diepold, A. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab055 · Cited by 66

Stable InSe transistors with high-field effect mobility for reliable nerve signal sensing

Jiang, J., Li, J., Li, Y., Duan, J., Li, L., Tian, Y., Zong, Z., Zheng, H., Feng, X., Li, Q., et al. (2019) · npj 2D Materials and Applications · doi:10.1038/s41699-019-0110-x · Cited by 64

Neuroprotective potential of astroglia

Liu, B., Teschemacher, A. G., & Kasparov, S. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24140 · Cited by 65

Neurostimulation for Stroke Rehabilitation

Ting, W. K., Fadul, F. A.-R., Fecteau, S., & Éthier, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.649459 · Cited by 65

Optogenetics enlightens neuroscience drug discovery

Song, C., & Knöpfel, T. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.15 · Cited by 63

An Artificial Reflex Arc That Perceives Afferent Visual and Tactile Information and Controls Efferent Muscular Actions

Sun, L., Du, Y., Yu, H., Wei, H., Xu, W., & Xu, W. (2022) · Research · doi:10.34133/2022/9851843 · Cited by 61

Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis

Chaytow, H., Carroll, E., Gordon, D., Huang, Y.-T., van der Hoorn, D., Smith, H. L., Becker, T., Becker, C. G., Faller, K. M. E., Talbot, K., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104202 · Cited by 59

Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy

Magown, P., Shettar, B. C., Zhang, Y., & Rafuse, V. (2015) · Nature Communications · doi:10.1038/ncomms9506 · Cited by 58

Biobased Elastomer Nanofibers Guide Light‐Controlled Human‐iPSC‐Derived Skeletal Myofibers

Cheesbrough, A., Sciscione, F., Riccio, F., Harley, P., R’Bibo, L., Ziakas, G., Darbyshire, A., Lieberam, I., & Song, W. (2022) · Advanced Materials · doi:10.1002/adma.202110441 · Cited by 53

Optogenetic Medicine: Synthetic Therapeutic Solutions Precision-Guided by LightPreprint

Ye, H., & Fussenegger, M. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a034371 · Cited by 55

IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

Lehnen, D., Barral, S., Cardoso, T., Grealish, S., Heuer, A., Smiyakin, A., Kirkeby, A., Kollet, J., Cremer, H., Parmar, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.08.016 · Cited by 52

Non-viral delivery of an optogenetic tool into cells with self-healing hydrogel

Hsieh, F.-Y., Han, H., Chen, X., Yang, C., Wei, Y., & Hsu, S. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.014 · Cited by 52

In Vitro Modeling of Nerve–Muscle Connectivity in a Compartmentalized Tissue Culture Device

Machado, C. B., Pluchon, P., Harley, P., Rigby, M., Sabater, V. G., Stevenson, D. C., Hynes, S., Lowe, A., Burrone, J., Viasnoff, V., et al. (2019) · Advanced Biosystems · doi:10.1002/adbi.201800307 · Cited by 55

Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease

Bursac, N., Juhas, M. E., & Rando, T. A. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071114-040640 · Cited by 52

Optically-Induced Neuronal Activity Is Sufficient to Promote Functional Motor Axon Regeneration In Vivo

Ward, P. J., Jones, L. N., Mulligan, A., Goolsby, W. N., Wilhelm, J. C., & ENGLISH, A. W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154243 · Cited by 43

The evolution of nerve transfers for spinal cord injury

Bazarek, S. F., & Brown, J. M. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113426 · Cited by 44

Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo

Kushibiki, T., Okawa, S., Hirasawa, T., & Ishihara, M. (2015) · Gene Therapy · doi:10.1038/gt.2015.23 · Cited by 43

Implantable Micro-Light-Emitting Diode (µLED)-based optogenetic interfaces toward human applications

Lee, J. H., Lee, S., Kim, D., & Lee, K. J. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114399 · Cited by 43

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch

Lin, W., Jia, X., Shi, X., He, Q., Zhang, P., Zhang, X., Zhang, L., Wu, M., Ren, T., Liu, Y., et al. (2025) · Science · doi:10.1126/science.adp0176 · Cited by 41

Optical cuff for optogenetic control of the peripheral nervous system

Michoud, F., Sottas, L., Browne, L. E., Asboth, L., Latrémolière, A., Sakuma, M., Courtine, G., Woolf, C. J., & Lacour, S. P. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa9126 · Cited by 40

Analysis of Signaling Endosome Composition and Dynamics Using SILAC in Embryonic Stem Cell-Derived Neurons

Debaisieux, S., Encheva, V., Chakravarty, P., Snijders, A. P., & Schiavo, G. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.051649 · Cited by 38

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells

Nadadhur, A. G., Emperador-Melero, J., Meijer, M., Schut, D., Jacobs, G., Li, K. W., Hjorth, J. J. J., Meredith, R. M., Toonen, R. F. G., van Kesteren, R. E., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178533 · Cited by 37

Illuminating Parkinson's therapy with optogenetics

Chen, Y., Xiong, M., & Zhang, S. (2015) · Nature Biotechnology · doi:10.1038/nbt.3140 · Cited by 33

Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains

Lei, W., Li, W., Ge, L., & Chen, G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00131 · Cited by 34

Optogenetic neuronal stimulation promotes axon outgrowth and myelination of motor neurons in a three‐dimensional motor neuron–Schwann cell coculture model on a microfluidic biochip

Hyung, S., Lee, B., Kim, Y. J., Bang, S., Tahk, D., Park, J., Suh, J. F., & Jeon, N. L. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27083 · Cited by 31

Actuated tissue engineered muscle grafts restore functional mobility after volumetric muscle loss

Rousseau, E. B., Raman, R., Tamir, T. Y., Bu, A., Srinivasan, S. S., Lynch, N., Langer, R., White, F. M., & Cima, M. J. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122317 · Cited by 30

Cardiac optogenetics: a novel approach to cardiovascular disease therapy

Jiang, C., Li, H. T., Zhou, Y. M., Wang, X., Wang, L., & Liu, Z. Q. (2017) · EP Europace · doi:10.1093/europace/eux345 · Cited by 31

A Hybridization of Cuckoo Search and Differential Evolution for the Logistics Distribution Center Location Problem

Chi, R., Su, Y., Qu, Z., & Chi, X. (2019) · Mathematical Problems in Engineering · doi:10.1155/2019/7051248 · Cited by 29

Overview on Research and Clinical Applications of Optogenetics

Towne, C. L., & Thompson, K. R. (2016) · Current Protocols in Pharmacology · doi:10.1002/cpph.13 · Cited by 29

On-demand optogenetic activation of human stem-cell-derived neurons

Klapper, S. D., Sauter, E. J., Swiersy, A., Hyman, M. A. E., Bamann, C., Bamberg, E., & Busskamp, V. (2017) · Scientific Reports · doi:10.1038/s41598-017-14827-6 · Cited by 28

Towards the clinical translation of optogenetic skeletal muscle stimulation

Gundelach, L. A., Hüser, M. A., Beutner, D., Ruther, P., & Bruegmann, T. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02387-0 · Cited by 30

Restoring motor function using optogenetics and neural engraftment

Bryson, J. B., Machado, C. B., Lieberam, I., & Greensmith, L. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.02.016 · Cited by 24

Functional imaging for regenerative medicine

Leahy, M. J., Thompson, K., Zafar, H., Alexandrov, S., Foley, M. J., O’Flatharta, C., & Dockery, P. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0315-2 · Cited by 27

Human Induced Pluripotent Stem Cell–Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury

Pepper, J., Wang, T. V., Hennes, V., Sun, S. Y., & Ichida, J. K. (2016) · JAMA Facial Plastic Surgery · doi:10.1001/jamafacial.2016.1544 · Cited by 27

Subtype diversification and synaptic specificity of stem cell-derived spinal interneurons

Hoang, P. T., Chalif, J. I., Bikoff, J. B., Jessell, T. M., Mentis, G. Z., & Wichterle, H. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.016 · Cited by 25

Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish

Allodi, I., & Hedlund, E. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00109 · Cited by 31

Stem Cell Neurodevelopmental Solutions for Restorative Treatments of the Human Trunk and Spine

Olmsted, Z. T., & Paluh, J. L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.667590 · Cited by 25

Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates

Williams, J. J., Watson, A. M., Vazquez, A. L., & Schwartz, A. B. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00759 · Cited by 23

Optogenetic neuromuscular actuation of a miniature electronic biohybrid robot

Min, H., Wang, Y., Wang, J., Li, X., Kim, W., Aydin, O., Kang, S., You, J., Lim, J., Wolhaupter, K., et al. (2025) · Science Robotics · doi:10.1126/scirobotics.adu5830 · Cited by 25

A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies

Liu, F., Wu, Y., Almarri, N., Habibollahi, M., Lancashire, H. T., Bryson, J. B., Greensmith, L., Jiang, D., & Demosthenous, A. (2022) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2022.3202026 · Cited by 21

Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections

Paredes‐Redondo, A., Harley, P., Maniati, E., Ryan, D., Louzada, S., Meng, J., Kowala, A., Fu, B., Yang, F., Liu, P., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi8787 · Cited by 20

Optogenetic activation of muscle contraction in vivo

Ganji, E., Chan, C. S., Ward, C. W., & Killian, M. L. (2020) · Connective Tissue Research · doi:10.1080/03008207.2020.1798943 · Cited by 19

Peripheral optogenetic stimulation induces whisker movement and sensory perception in head-fixed mice

Park, S., Bandi, A., Lee, C. R., & Margolis, D. J. (2016) · eLife · doi:10.7554/elife.14140 · Cited by 22

Transplantation of embryonic spinal cord neurons to the injured distal nerve promotes axonal regeneration after delayed nerve repair

Zhang, W., Fang, X., Zhang, C., Li, W., Wong, W. M., Xu, Y., Wu, W., & Lin, J. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13495 · Cited by 19

Optical Stimulation for Restoration of Motor Function After Spinal Cord Injury

Mallory, G. W., Grahn, P. J., Hachmann, J. T., Luján, J. L., & Lee, K. H. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.12.004 · Cited by 18

Transgenic GDNF Positively Influences Proliferation, Differentiation, Maturation and Survival of Motor Neurons Produced from Mouse Embryonic Stem Cells

Cortés, D., Robledo-Arratia, Y., Hernandez-Martinez, R., Escobedo-Ávila, I., Bargas, J., & Velasco, I. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00217 · Cited by 18

Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells

Pomeroy, J. E., Nguyen, H. X., Hoffman, B. D., & Bursac, N. (2017) · Theranostics · doi:10.7150/thno.20593 · Cited by 18

Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease

Inglés‐Prieto, Á., Furthmann, N., Crossman, S. H., Tichy, A., Hoyer, N., Petersen, M., Zheden, V., Biebl, J., Reichhart, E., Gyoergy, A., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009479 · Cited by 18

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons

Bu, A., Afghah, F., Castro, N., Bawa, M., Kohli, S., Shah, K., Rios, B., Butty, V. L., & Raman, R. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403712 · Cited by 17

Optogenetics Applications for Treating Spinal Cord Injury

Ahmad, A., Ashraf, S., & Komai, S. (2015) · Asian Spine Journal · doi:10.4184/asj.2015.9.2.299 · Cited by 19

Microflow-mediated optical assembly of nanoparticles with femtogram protein via shrinkage of light-induced bubbles

Ueda, M., Nishimura, Y., Tamura, M., Ito, S., Tokonami, S., & Iida, T. (2019) · APL Photonics · doi:10.1063/1.5079306 · Cited by 17

Optogenetics: Novel Tools for Controlling Mammalian Cell Functions with Light

Kushibiki, T., Okawa, S., Hirasawa, T., & Ishihara, M. (2014) · International Journal of Photoenergy · doi:10.1155/2014/895039 · Cited by 17

Synthetic mechanobiology: engineering cellular force generation and signaling

Hughes, J. H., & Kumar, S. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.03.004 · Cited by 17

In vitro models of spinal motor circuit’s development in mammals: achievements and challenges

Nedelec, S., & Martínez-Arias, A. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.12.002 · Cited by 14

Restoring the sense of touch

Anikeeva, P., & Koppes, R. A. (2015) · Science · doi:10.1126/science.aad0910 · Cited by 16

Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis

Pagan‐Diaz, G. J., Drnevich, J. M., Ramos-Cruz, K. P., Sam, R., Sengupta, P., & Bashir, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-68988-y · Cited by 16

Human pluripotent stem cell tools for cardiac optogenetics

Zhuge, Y., Patlolla, B., Ramakrishnan, C., Beygui, R. E., Zarins, C. K., Deisseroth, K. A., Ellen Kuhl, A., & Abilez, O. J. (2014) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2014.6945038 · Cited by 16

Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini

Ramos, S. I., Makeyev, E. V., Salierno, M. J., Kodama, T., Kawakami, Y., & Sahara, S. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.01.036 · Cited by 16

Tumor prevention facilitates delayed transplant of stem cell‐derived motoneurons

Magown, P., Brownstone, R. M., & Rafuse, V. F. (2016) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.327 · Cited by 14

Optogenetics for neural transplant manipulation and functional analysis

Habibey, R., Sharma, K., Swiersy, A., & Busskamp, V. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.01.141 · Cited by 14

Boundary Cap Neural Crest Stem Cells Promote Survival of Mutant SOD1 Motor Neurons

Aggarwal, T., Hoeber, J., Ivert, P., Vasylovska, S., & Kozlova, E. N. (2017) · Neurotherapeutics · doi:10.1007/s13311-016-0505-8 · Cited by 14

hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation

Heuer, A., Kirkeby, A., Pfisterer, U., Jönsson, M. E., & Parmar, M. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.027 · Cited by 14

A brain center that controls consummatory responses

Canovas, J. A., Wang, L., Mohamed, A. A. M., Abbott, L. F., & Zuker, C. S. (2025) · Cell · doi:10.1016/j.cell.2025.08.021 · Cited by 15

Optogenetics in cancer drug discovery

Kiełbus, M., Czapiński, J., Odrzywolski, A., Stasiak, G., Szymanska, K., Kałafut, J., Kos, M., Giannopoulos, K., Stepulak, A., & Rivero‐Müller, A. (2018) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1437138 · Cited by 13

Connectivity and circuitry in a dish versus in a brain

Chinchalongporn, V., Koppensteiner, P., Prè, D., Thangnipon, W., Bilo, L., & Arancio, O. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0129-y · Cited by 15

Establishment of a Human Induced Pluripotent Stem Cell-Derived Neuromuscular Co-Culture Under Optogenetic ControlPreprint

Swartz, E. W., Shintani, G., Wan, J., Maffei, J. S., Wang, S. H., Miller, B. L., Havton, L. A., & Coppola, G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.10.036400 · Cited by 13

Endomicroscopy and electromyography of neuromuscular junctions in situ

Brown, R., Dissanayake, K. N., Skehel, P., & Ribchester, R. R. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.124 · Cited by 12

Advances in Optogenetics Applications for Central Nervous System Injuries

Geng, Y., Li, Z., Zhu, J., Du, C., Yuan, F., Cai, X., Ali, A., Yang, J., Tang, C., Cong, Z., et al. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0290 · Cited by 12

Clinical applicability of optogenetic gene regulation

Wichert, N., Witt, M., Blume, C. A., & Scheper, T. H. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27895 · Cited by 15

An Integrated Bidirectional Multi-Channel Opto-Electro Arbitrary Waveform Stimulator for Treating Motor Neurone Disease

Jiang, D., Wu, Y., Almarri, N., Habibollahi, M., Liu, F., Bryson, J. B., Greensmith, L., & Demosthenous, A. (2021) · 2021 IEEE International Symposium on Circuits and Systems (ISCAS) · doi:10.1109/iscas51556.2021.9401220 · Cited by 11

Spot light on skeletal muscles: optogenetic stimulation to understand and restore skeletal muscle function

Bremen, T. V., Send, T., Sasse, P., & Bruegmann, T. (2017) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-017-9481-9 · Cited by 12

Restoring motor function using optogenetics and neural engraftment

Bryson, J. B., Machado, C. B., Lieberam, I., & Greensmith, L. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.02.016 · Cited by 24

Using Optogenetics and Stem Cell-derived Neural Engraftment Techniques to Restore Lost Motor Function

Bryson, J. B., & Greensmith, L. (2017) · Cambridge University Press eBooks · doi:10.1017/9781107281875.023

MOTOR FUNCTION RESTORATION: THERAPEUTIC APPROACHES TO DENERVATION PATHOLOGIES

Magown, P. (2016) · DalSpace (Dalhousie University)

Let there be light and muscle contraction: optogenetic restoration of muscle function.

Gologorsky, Y., & Chi, J. (2014) · PubMed · doi:10.1227/01.neu.0000452317.84236.3e

Using stem cells and light to restore function to paralysed muscles

Bryson, J. B., & Greensmith, L. (2017) · Neuromuscular Disorders · doi:10.1016/s0960-8966(17)30219-5