Enabling the genomic revolution in Africa
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H3Africa is developing capacity for health-related genomics research in Africa
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Assessments of PRS across diverse populations are becoming increasingly feasible with the growth and public availability of global biobanks as well as diversifying priorities from funding agencies.
“These assessments are becoming increasingly feasible with the growth and public availability of global bio banks as well as diversifying priorities from funding agencies55,56.”
From Clinical use of current polygenic risk scores may exacerbate health disparities (2019) · cites this paper as [55]
In “Enabling the genomic revolution in Africa” (page not provided), the paper describes funding for H3Africa and plans to make its genomic data publicly accessible through an access committee. It does not discuss polygenic risk score (PRS) assessments or establish that growing global biobanks and diversifying funding priorities are making those assessments increasingly feasible. (LLM, conf=0.80)
Experimental — accuracy not yet measuredThe H3Africa Initiative has increased genomics research capacity in Africa through more than $216 million in funding from the NIH (USA) and Wellcome Trust (UK) for genetics research led by African investigators.
“The most notable investment here comes from the Human Heredity and Health in Africa (H3Africa) Initiative, increasing genomics research capacity in Africa through more than $216 million in funding from the NIH (USA) and Wellcome Trust (UK) for genetics research led by African investigators55,74.”
From Clinical use of current polygenic risk scores may exacerbate health disparities (2019) · cites this paper as [55]
In “Enabling the genomic revolution in Africa” (page unavailable), the paper says the NIH and Wellcome Trust fund H3Africa, which focuses on capacity building and awards research grants directly to African institutions with African principal investigators. It gives the funding amount as $76 million over five years, not more than $216 million. (LLM, conf=0.90)
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Research works printed but not linked: 10
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- Authors
- The H3Africa Consortium, Matovu, E., Bucheton, B., Chisi, J., Enyaru, J., Hertz-Fowler, C., Koffi, M., Macleod, A., Mumba, D., Sidibe, I., Simo, G., Simuunza, M., Mayosi, B., Ramesar, R., Mulder, N., Ogendo, S., Mocumbi, A. O., Hugo-Hamman, C., Ogah, O., El Sayed, A., Mondo, C., Musuku, J., Engel, M., De Vries, J., Lesosky, M., Shaboodien, G., Cordell, H., Paré, G., Keavney, B., Motala, A., Sobngwi, E., Mbanya, J. C., Hennig, B., Balde, N., Nyirenda, M., Oli, J., Adebamowo, C., Levitt, N., Mayige, M., Kapiga, S., Kaleebu, P., Sandhu, M., Smeeth, L., McCarthy, M., & Rotimi, C.
- Affiliations
- National Institutes of Health (US)
- Stellenbosch University (ZA)
- University of Maryland, Baltimore (US)
- Covenant University (NG)
- University of Ibadan (NG)
- University for Development Studies (GH)
- University of Abuja (NG)
- University of Ghana (GH)
- Walter Sisulu University (ZA)
- Zagazig University (EG)
- Baylor University (US)
- Broad Institute (US)
- Wellcome Trust (GB)
- University of Michigan (US)
- Rutgers, The State University of New Jersey (US)
- Baylor College of Medicine (US)
- Uniformed Services University of the Health Sciences (US)
- University of the Witwatersrand (ZA)
- University of Malawi (MW)
- University of the Western Cape (ZA)
- ORCID
- Matovu, Enock
- Bucheton, Bruno
- Koffi, Mathurin
- Macleod, Annette
- Simo, Gustave
- Simuunza, Martin
- Mayosi, Bongani
- Mulder, Nicola
- Mocumbi, Ana Olga
- Hugo-Hamman, Christopher
- Ogah, Okechukwu
- Mondo, Charles
- Engel, Mark
- Lesosky, Maia
- Shaboodien, Gasnat
- Cordell, Heather
- Paré, Guillaume
- Keavney, Bernard
- Motala, Ayesha
- Mbanya, Jean Claude
- Hennig, Branwen
- Nyirenda, Moffat
- Adebamowo, Clement
- Levitt, Naomi
- Mayige, Mary
- Kapiga, Saidi
- Kaleebu, Pontiano
- Sandhu, Manjinder
- Smeeth, Liam
- McCarthy, Mark
- Rotimi, Charles
- Venue
- Science
- Published
- 2014-06-20
- Volume
- 344
- Issue
- 6190
- Pages
- 1346-1348
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4138491
- OpenAlex
- W2002732332
- Cited by
- 519
- References
- 0
- Citations by year
- 2026: 53 · 2025: 54 · 2024: 35 · 2023: 56 · 2022: 44 · 2021: 48 · 2020: 45 · 2019: 38 · 2018: 37 · 2017: 40 · 2016: 26 · 2015: 33 · 2014: 10
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Civil War Book Review (submittedVersion)
- HAL (submittedVersion)
- Funders
- Wellcome Trust (099310/Z/12/Z, 085349, 098504, 098610, 104111, 095009, 095201, 093727, 099313)
- National Institute for Health and Care Research (NF-SI-0510-10090)
- British Heart Foundation (RG/08/012/25941)
- National Heart, Lung, and Blood Institute (U24HL135600)
- National Human Genome Research Institute (U24HG006941, U01HG007044, U24HG007008, U01HG007459, U54HG006947, U54HG006939, UH2HG007051, U41HG006941, U01HG009716, U54HG007479, UH3HG007008, U54HG006938)
- National Institute of Allergy and Infectious Diseases (U54AI110398, R01AI104621, U19AI089696)
- Fogarty International Center (U2RTW010679, D43TW009140)
- National Institute of Neurological Disorders and Stroke (R01NS107900)
- National Institute on Minority Health and Health Disparities (P20MD006899)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genetics, Bioinformatics, and Biomedical Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Biotechnology and Related Fields
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
- Keywords
- H3Africa, Africa, research capacity building
- MeSH terms
- Africa, Disease, England, Genetics, Medical, Health, Humans, National Institutes of Health (U.S.), United States, Genomics, Genome-Wide Association Study
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