The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert
Abstract
Resident memory T cells sound the alarm: Immunological memory protects against reinfection. Resident memory T cells (T RM ) are long-lived and remain in the tissues where they first encountered a pathogen (see the Perspective by Carbone and Gebhardt). Schenkel et al. and Ariotti et al. found that CD8 + T RM cells act like first responders in the female reproductive tissue or the skin of mice upon antigen reencounter. By secreting inflammatory proteins, T RM cells rapidly activated local immune cells to respond, so much so that they protected against infection with an unrelated pathogen. Iijima and Iwasaki found that CD4 + T RM cells protected mice against reinfection with intravaginal herpes simplex virus 2. Science , this issue p. 98 , p. 101 , p. 93 ; see also p. 40
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Cites
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Gene ontology analysis for RNA-seq: accounting for selection bias
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Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
Hansen, S. G., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., Whizin, N., Oswald, K., Shoemaker, R., Swanson, T., et al. (2011) · Nature · doi:10.1038/nature10003 · Cited by 988
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity
Jiang, X., Clark, R. A., Liu, L., Wagers, A. J., Fuhlbrigge, R. C., & Kupper, T. S. (2012) · Nature · doi:10.1038/nature10851 · Cited by 891
A vaccine strategy that protects against genital herpes by establishing local memory T cells
Shin, H., & Iwasaki, A. (2012) · Nature · doi:10.1038/nature11522 · Cited by 646
Sensing and alarm function of resident memory CD8+ T cells
Schenkel, J. M., Fraser, K. A., Vezys, V., & Masopust, D. (2013) · Nature Immunology · doi:10.1038/ni.2568 · Cited by 640
Mackay, L. K., Stock, A. T., Ma, J. Z., Jones, C. M., Kent, S. J., Mueller, S. N., Heath, W. R., Carbone, F. R., & Gebhardt, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202288109 · Cited by 635
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Cited by
Human T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257
Tissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
“Importantly, Trm cell-dependent activation of parenchymal, innate, and adaptive immunity triggered the induction of a local protective antiviral state (Ariotti et al., 2014; Schenkel et al., 2014b).”
BackgroundHobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
Mackay, L. K., Minnich, M., Kragten, N. A. M., Liao, Y., Nota, B., Seillet, C., Zaid, A., Man, K., Preston, S., Freestone, D., et al. (2016) · Science · doi:10.1126/science.aad2035 · Cited by 1,010
Tissue-resident memory T cells: local specialists in immune defence
Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006
CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin
Cheuk, S., Schlums, H., Gallais Sérézal, I., Martini, E., Chiang, S. C., Marquardt, N., Gibbs, A., Detlofsson, E., Introini, A., Forkel, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.009 · Cited by 678
Metadata
- Authors
- Ariotti, S., Hogenbirk, M. A., Dijkgraaf, F. E., Visser, L. L., Hoekstra, M. E., Song, J.-Y., Jacobs, H., Haanen, J. B., & Schumacher, T. N.
- Venue
- Science
- Published
- 2014-10-03
- Volume
- 346
- Issue
- 6205
- Pages
- 101-105
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2140368190
- Cited by
- 533
- References
- 23
- FWCI
- 15.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ariotti, S., Hogenbirk, M. A., Dijkgraaf, F. E., Visser, L. L., Hoekstra, M. E., Song, J.-Y., Jacobs, H., Haanen, J. B., & Schumacher, T. N. (2014). Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert. Science. https://doi.org/10.1126/science.1254803
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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