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Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans
Open accessAbstract
Lysosomes signal the nucleus to control aging: Folick et al. propose a mechanism by which a lysosomal enzyme influences nuclear events that control longevity in the worm (see the Perspective by Shuo and Brunet). Increased expression of the lysosomal acid lipase LIPL-4 increased longevity, and this effect depended on the presence of the lysosomal lipid-binding protein LBP-8. LBP-8 acts as a chaperone that helps carry lipds to the nucleus. The authors identified the fatty acid oleoylethanolamide (OEA) as a potential signaling molecule whose transport to the nucleus could activate nuclear hormone receptors and transcription factors NHR-49 and NHR-80. The transcriptional targets of NHR-49 and NHR-80 in turn regulate longevity. Science , this issue p. 83
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Metadata
- Authors
- Folick, A., Oakley, H. D., Yu, Y., Armstrong, E. H., Kumari, M., Sanor, L., Moore, D. D., Ortlund, E. A., Zechner, R., & Wang, M. C.
- Venue
- Science
- Published
- 2015-01-02
- Volume
- 347
- Issue
- 6217
- Pages
- 83-86
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2136704793
- Cited by
- 280
- References
- 0
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Folick, A., Oakley, H. D., Yu, Y., Armstrong, E. H., Kumari, M., Sanor, L., Moore, D. D., Ortlund, E. A., Zechner, R., & Wang, M. C. (2015). Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Science. https://doi.org/10.1126/science.1258857
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