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Restricted epigenetic inheritance of H3K9 methylation
Open accessAbstract
Inheritance of a covalent histone modification: Genomic DNA is the repository of all genetic information and is packaged into chromatin. Chromatin is also a repository of regulatory information in the form of covalent marks added to the histones that package the DNA. These marks can determine tissue- and organ-specific gene expression patterns, which must be transmitted to daughter cells to maintain their identity. Ragunathan et al. and Audergon et al. show that in fission yeast, a chromatin mark, like genetic information, can be inherited across many cell generations. The mark can be inherited independently of DNA sequence, DNA methylation, or RNA interference. Thus, histone marks constitute true epigenetic information. Science , this issue 10.1126/science.1258699 ; see also p. 132
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“Indeed, inherited epigenetic patterns (254–256) and environmental factors (257, 258) other than childhood trauma (such as heavy metals (259), parenting style, and early trauma such as maternal separation (260)) may all impact the epigenetic pattern and hence childhood trauma-induced differential health outcomes.”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [256]
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“By contrast, in the absence of RNAi-dependent amplification, H3K9me3 alone is insufficient to drive stable epigenetic memory, unless the histone demethylase Epe1 is mutated 47,102 .”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [102]
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“In yeast, TEI has been well-documented 101 and is known to involve RNAi-dependent heterochromatin deposition, leading to Clr4dependent H3K9me3 marking of silent heterochromatin 47,102 .”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [102]
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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., & Kouzarides, T. (2001) · Nature · doi:10.1038/35065138 · Cited by 2,903
Self-citationMethylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868
Histone demethylation by a family of JmjC domain-containing proteins
Tsukada, Y.-I., Fang, J., Erdjument‐Bromage, H., Warren, M., Borchers, C. H., Tempst, P., & Zhang, Y. (2005) · Nature · doi:10.1038/nature04433 · Cited by 2,171
Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly
Nakayama, J.-I., Rice, J. C., Strahl, B. D., Allis, C. D., & Grewal, S. I. S. (2001) · Science · doi:10.1126/science.1060118 · Cited by 1,739
RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond
Castel, S. E., & Martienssen, R. A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3355 · Cited by 963
Dynamics and Memory of Heterochromatin in Living Cells
Hathaway, N. A., Bell, O., Hodges, C., Miller, E. L., Neel, D. S., & Crabtree, G. R. (2012) · Cell · doi:10.1016/j.cell.2012.03.052 · Cited by 446
Aagaard, L., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P. B., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1923 · Cited by 441
Zhang, K., Mosch, K., Fischle, W., & Grewal, S. I. S. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1406 · Cited by 389
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Chen, E. S., Zhang, K., Nicolas, E., Cam, H. P., Zofall, M., & Grewal, S. I. S. (2008) · Nature · doi:10.1038/nature06561 · Cited by 356
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Metadata
- Authors
- Audergon, P. N. C. B., Catania, S., Kagansky, A., Tong, P., Shukla, M., Pidoux, A. L., & Allshire, R. C.
- Affiliations
- Wellcome Centre for Cell Biology (GB)
- Corresponding author
- Allshire, Robin C.
- ORCID
- Venue
- Science
- Published
- 2015-04-03
- Volume
- 348
- Issue
- 6230
- Pages
- 132-135
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4397586
- OpenAlex
- W2105077884
- Cited by
- 254
- References
- 32
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 29 · 2023: 20 · 2022: 21 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 15 · 2017: 35 · 2016: 26 · 2015: 13
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ERA (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (93852)
- Wellcome Trust Principal Research Fellowship (95021)
- EC-NOE-EpiGeneSys (HEALTH-F4-2010-257082)
- Wellcome Trust Centre for Cell Biology (92076)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- H3K9 methylation, epigenetic inheritance, heterochromatin, Clr4, histone demethylase, histone methyltransferase, transgenerational inheritance, meiosis, mitotic inheritance, Schizosaccharomyces pombe
- MeSH terms
- Heterochromatin, Histones, Lysine, Methylation, Methyltransferases, Mutation, Nuclear Proteins, Histone-Lysine N-Methyltransferase, Protein Processing, Post-Translational, Schizosaccharomyces, Cell Cycle Proteins, Schizosaccharomyces pombe Proteins, Epigenesis, Genetic
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