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Restricted epigenetic inheritance of H3K9 methylation
Open accessAbstract
Inheritance of a covalent histone modification: Genomic DNA is the repository of all genetic information and is packaged into chromatin. Chromatin is also a repository of regulatory information in the form of covalent marks added to the histones that package the DNA. These marks can determine tissue- and organ-specific gene expression patterns, which must be transmitted to daughter cells to maintain their identity. Ragunathan et al. and Audergon et al. show that in fission yeast, a chromatin mark, like genetic information, can be inherited across many cell generations. The mark can be inherited independently of DNA sequence, DNA methylation, or RNA interference. Thus, histone marks constitute true epigenetic information. Science , this issue 10.1126/science.1258699 ; see also p. 132
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“Indeed, inherited epigenetic patterns (254–256) and environmental factors (257, 258) other than childhood trauma (such as heavy metals (259), parenting style, and early trauma such as maternal separation (260)) may all impact the epigenetic pattern and hence childhood trauma-induced differential health outcomes.”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [256]
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“By contrast, in the absence of RNAi-dependent amplification, H3K9me3 alone is insufficient to drive stable epigenetic memory, unless the histone demethylase Epe1 is mutated 47,102 .”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [102]
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“In yeast, TEI has been well-documented 101 and is known to involve RNAi-dependent heterochromatin deposition, leading to Clr4dependent H3K9me3 marking of silent heterochromatin 47,102 .”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [102]
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The molecular hallmarks of epigenetic control
Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809
Advances in epigenetics link genetics to the environment and disease
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Metadata
- Authors
- Audergon, P. N. C. B., Catania, S., Kagansky, A., Tong, P., Shukla, M., Pidoux, A. L., & Allshire, R. C.
- Affiliations
- Wellcome Centre for Cell Biology (GB)
- Corresponding author
- Allshire, Robin C.
- ORCID
- Venue
- Science
- Published
- 2015-04-03
- Volume
- 348
- Issue
- 6230
- Pages
- 132-135
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4397586
- OpenAlex
- W2105077884
- Cited by
- 254
- References
- 32
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 29 · 2023: 20 · 2022: 21 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 15 · 2017: 35 · 2016: 26 · 2015: 13
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ERA (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (93852)
- Wellcome Trust Principal Research Fellowship (95021)
- EC-NOE-EpiGeneSys (HEALTH-F4-2010-257082)
- Wellcome Trust Centre for Cell Biology (92076)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- H3K9 methylation, epigenetic inheritance, heterochromatin, Clr4, histone demethylase, histone methyltransferase, transgenerational inheritance, meiosis, mitotic inheritance, Schizosaccharomyces pombe
- MeSH terms
- Heterochromatin, Histones, Lysine, Methylation, Methyltransferases, Mutation, Nuclear Proteins, Histone-Lysine N-Methyltransferase, Protein Processing, Post-Translational, Schizosaccharomyces, Cell Cycle Proteins, Schizosaccharomyces pombe Proteins, Epigenesis, Genetic
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