The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
Open accessAbstract
Mechanisms propelling drug resistance: If it were to spread, resistance to the drug artemisinin would seriously derail the recent gains of global malaria control programs (see the Perspective by Sibley). Mutations in a region called the K13-propeller are predictive for artemisinin resistance in Southeast Asia. Mok et al. looked at the patterns of gene expression in parasites isolated from more than 1000 patients sampled in Africa, Bangladesh, and the Mekong region. A range of mutations that alter protein repair pathways and the timing of the parasite's developmental cycle were only found in parasites from the Mekong region. Straimer et al. genetically engineered the K13 region of parasites obtained from recent clinical isolates. Mutations in this region were indeed responsible for the resistance phenotypes. Science , this issue p. 431 , p. 428 ; see also p. 373
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Artemisinin Resistance in Plasmodium falciparum Malaria
Dondorp, A. M., Nosten, F., Yi, P., Das, D., Phyo, A. P., Tarning, J., Lwin, K. M., Ariey, F., Hanpithakpong, W., Lee, S. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808859 · Cited by 3,424
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Ashley, E. A., Dhorda, M., Fairhurst, R. M., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J. M., Mao, S., Sam, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314981 · Cited by 2,205
Self-citationA new global malaria eradication strategy
Feachem, R., & Sabot, O. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60424-9 · Cited by 183
Cited by
Antimalarial Drug Resistance: A Threat to Malaria Elimination
Menard, D., & Dondorp, A. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025619 · Cited by 499
Artemisinin Action and Resistance in Plasmodium falciparum
Tilley, L., Straimer, J., Gnädig, N. F., Ralph, S. A., & Fidock, D. A. (2016) · Trends in Parasitology · doi:10.1016/j.pt.2016.05.010 · Cited by 359
Self-citationMolecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
Wicht, K. J., Mok, S., & Fidock, D. A. (2020) · Annual Review of Microbiology · doi:10.1146/annurev-micro-020518-115546 · Cited by 322
Self-citationBiology of Malaria Transmission
Meibalan, E., & Marti, M. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025452 · Cited by 251
Xie, D.-Y., Ma, D.-M., Judd, R., & Jones, A. L. (2016) · Phytochemistry Reviews · doi:10.1007/s11101-016-9480-2 · Cited by 63
Metadata
- Authors
- Straimer, J., Gnädig, N. F., Witkowski, B., Amaratunga, C., Duru, V., Ramadani, A. P., Dacheux, M., Khim, N., Zhang, L., Lam, S., Gregory, P. D., Urnov, F. D., Mercereau-Puijalon, O., Benoit-Vical, F., Fairhurst, R. M., Ménard, D., & Fidock, D. A.
- Venue
- Science
- Published
- 2015-01-23
- Volume
- 347
- Issue
- 6220
- Pages
- 428-431
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993347313
- Cited by
- 728
- References
- 3
- FWCI
- 61.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Straimer, J., Gnädig, N. F., Witkowski, B., Amaratunga, C., Duru, V., Ramadani, A. P., Dacheux, M., Khim, N., Zhang, L., Lam, S., Gregory, P. D., Urnov, F. D., Mercereau-Puijalon, O., Benoit-Vical, F., Fairhurst, R. M., Ménard, D., & Fidock, D. A. (2015). K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science. https://doi.org/10.1126/science.1260867
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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