Persisters unmasked
Abstract
Intracellular toxins cause bacterial growth arrest and antibiotic tolerance
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bacterial drug persistence is transient and mediated by phenotypic plasticity rather than genetic alterations.
“demonstrating that bacterial drug persistence is transient and mediated by phenotypic plasticity rather than genetic alterations (Figure 2A) [31,32].”
From Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer (2021) · cites this paper as [31]
Cites
2 retracted
RETRACTED: Bacterial persistence by RNA endonucleases
Maisonneuve, E., Shakespeare, L. J., Jørgensen, M. G., & Gerdes, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100186108 · Cited by 473 · see citing works
RetractedMaisonneuve, E., Castro-Camargo, M., & Gerdes, K. (2013) · Cell · doi:10.1016/j.cell.2013.07.048 · Cited by 439 · see citing works
RetractedBacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952 · see citing works
TREATMENT OF STAPHYLOCOCCAL INFECTIONS WITH PENICILLIN BY INTERMITTENT STERILISATION
Bigger, J. (1944) · The Lancet · doi:10.1016/s0140-6736(00)74210-3 · Cited by 1,164 · see citing works
Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters
Hélaine, S., Cheverton, A. M., Watson, K. G., Faure, L. M., Matthews, S. A., & Holden, D. W. (2014) · Science · doi:10.1126/science.1244705 · Cited by 744 · see citing works
Self-citationMolecular Mechanisms Underlying Bacterial Persisters
Maisonneuve, E., & Gerdes, K. (2014) · Cell · doi:10.1016/j.cell.2014.02.050 · Cited by 644 · see citing works
Moyed, H. S., & Bertrand, K. P. (1983) · Journal of Bacteriology · doi:10.1128/jb.155.2.768-775.1983 · Cited by 632 · see citing works
Non-genetic individuality: chance in the single cell
Spudich, J. L., & Koshland, D. E. (1976) · Nature · doi:10.1038/262467a0 · Cited by 522 · see citing works
Observations on the Mechanism of Action of Penicillin.
Hobby, G. L., Meyer, K., & Chaffee, E. (1942) · Experimental Biology and Medicine · doi:10.3181/00379727-50-13773 · Cited by 458 · see citing works
Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence
Rotem, E., Loinger, A., Ronin, I., Levin-Reisman, I., Gabay, C., Noam Shoresh, F., Biham, O., & Balaban, N. Q. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004333107 · Cited by 351 · see citing works
Phenotypic Variation of Salmonella in Host Tissues Delays Eradication by Antimicrobial Chemotherapy
Claudi, B., Spröte, P., Chirkova, A., Personnic, N., Zankl, J., Schürmann, N., Schmidt, A., & Bumann, D. (2014) · Cell · doi:10.1016/j.cell.2014.06.045 · Cited by 311 · see citing works
Allostery and Intrinsic Disorder Mediate Transcription Regulation by Conditional Cooperativity
Garcia‐Pino, A., Balasubramanian, S., Wyns, L., Gazit, E., Greve, H. D., Magnuson, R. D., Charlier, D., van Nuland, N. A. J., & Loris, R. (2010) · Cell · doi:10.1016/j.cell.2010.05.039 · Cited by 253 · see citing works
Programmed Heterogeneity: Epigenetic Mechanisms in Bacteria
Casadesús, J., & Low, D. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.472274 · Cited by 234 · see citing works
Okoro, C. K., Kingsley, R. A., Quail, M. A., Kankwatira, A., Feasey, N., Parkhill, J., Gordon Dougan, B., & Gordon, M. A. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cir1032 · Cited by 112 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
ATP-Dependent Persister Formation in <i>Escherichia coli</i>
Shan, Y., Brown Gandt, A., Rowe, S. E., Deisinger, J. P., Conlon, B. P., & Lewis, K. (2017) · mBio · doi:10.1128/mbio.02267-16 · Cited by 508 · see citing works
Guler, G. D., Tindell, C. A., Pitti, R., Wilson, C., Nichols, K., KaiWai Cheung, T., Kim, H.-J., Wongchenko, M., Yan, Y., Haley, B., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.002 · Cited by 277 · see citing works
Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer
Cabanos, H. F., & Hata, A. N. (2021) · Cancers · doi:10.3390/cancers13112666 · Cited by 189 · see citing works
- Authors
- Holden, D. W.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Holden, David W.
- ORCID
- Holden, David W.
- Venue
- Science
- Published
- 2015-01-02
- Volume
- 347
- Issue
- 6217
- Pages
- 30-32
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2408498868
- Cited by
- 34
- References
- 14
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 8 · 2015: 4
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council (MR/J006874/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- persister cells, antibiotic tolerance, intracellular toxin, antibiotic resistance, bacterial persistence
- MeSH terms
- Antitoxins, Bacteria, Bacterial Toxins, Drug Resistance, Bacterial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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