The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Lack of Protective Immunity Against Reinfection with Hepatitis C Virus
Abstract
Some individuals infected with hepatitis C virus (HCV) experience multiple episodes of acute hepatitis. It is unclear whether these episodes are due to reinfection with HCV or to reactivation of the original virus infection. Markers of viral replication and host immunity were studied in five chimpanzees sequentially inoculated over a period of 3 years with different HCV strains of proven infectivity. Each rechallenge of a convalescent chimpanzee with the same or a different HCV strain resulted in the reappearance of viremia, which was due to infection with the subsequent challenge virus. The evidence indicates that HCV infection does not elicit protective immunity against reinfection with homologous or heterologous strains, which raises concerns for the development of effective vaccines against HCV.
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Citations
Cites
A long-term study of hepatitis C virus replication in non-A, non-B hepatitis.
Farci, P., Alter, H. J., Wong, D., Miller, R. H., Shih, J. W., Jett, B., & Purcell, R. H. (1991) · New England Journal of Medicine · doi:10.1056/nejm199107113250205 · Cited by 571
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Cited by
Course and outcome of hepatitis C
Hoofnagle, J. H. (2002) · Hepatology · doi:10.1002/hep.1840360704 · Cited by 1,084
AASLD practice guidelines: Evaluation of the patient for liver transplantation†
Murray, K. F., & Carithers, R. L. (2005) · Hepatology · doi:10.1002/hep.20704 · Cited by 939
Memory CD8 + T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection
Shoukry, N. H., Grakoui, A., Houghton, M., Chien, D. Y., Ghrayeb, J., Reimann, K. A., & Walker, C. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030239 · Cited by 656
Quantitation of hepatitis C virus RNA in liver transplant recipients
Chazouilleres, O., Kim, M., Combs, C., Ferrell, L., Bacchetti, P., Roberts, J., Ascher, N. L., Neuwald, P., Wilber, J., Urdea, M., et al. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90759-5 · Cited by 277
Metadata
- Authors
- Farci, P., Alter, H. J., Govindarajan, S., Wong, D. C., Engle, R., Lesniewski, R. R., Mushahwar, I. K., Desai, S. M., Miller, R. H., Ogata, N., & Purcell, R. H.
- Venue
- Science
- Published
- 1992-10-02
- Volume
- 258
- Issue
- 5079
- Pages
- 135-140
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993023565
- Cited by
- 752
- References
- 1
- FWCI
- 28.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Farci, P., Alter, H. J., Govindarajan, S., Wong, D. C., Engle, R., Lesniewski, R. R., Mushahwar, I. K., Desai, S. M., Miller, R. H., Ogata, N., & Purcell, R. H. (1992). Lack of Protective Immunity Against Reinfection with Hepatitis C Virus. Science. https://doi.org/10.1126/science.1279801
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
