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Hyperphagia and Obesity Following Serotonin Depletion by Intraventricular p-Chlorophenylalanine
Abstract
Loss of brain serotonin was associated with overeating and increased body weight. Rats injected with p-chlorophenylalanine intraventricularly began overeating after 3 days and continued to display marked hyperphagia, primarily in the daytime, accompanied by increased body weight for 1 to 2 weeks. The effect was related to drug dose and to the degree and duration of serotonin depletion. Norepinephrine and dopamine levels were not significantly affected. It is concluded that p-chlorophenylalanine disinhibits feeding, as it does a number of other behaviors, by depleting serotonin. This suggests that hypothalamic lesions or dietary deficiencies which selectively and sufficiently deplete serotonin would lead to overeating.
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Cited by
Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F. (1986) · Peptides · doi:10.1016/0196-9781(86)90149-x · Cited by 849
The physiological psychology of hunger: a physiological perspective
Friedman, M. I., & Stricker, E. M. (1976) · Psychological Review · doi:10.1037/0033-295x.83.6.409 · Cited by 334
Samsel, A., & Seneff, S. (2013) · Entropy · doi:10.3390/e15041416 · Cited by 293
Feeding and reward: Perspectives from three rat models of binge eating
Corwin, R. L., Avena, N. M., & Boggiano, M. M. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.041 · Cited by 289
Lam, D. D., Przydzial, M. J., Ridley, S. H., Yeo, G. S. H., Rochford, J. J., O’Rahilly, S., & Heisler, L. K. (2008) · Endocrinology · doi:10.1210/en.2007-1321 · Cited by 270
Metadata
- Authors
- Breisch, S. T., Zemlan, F. P., & Hoebel, B. G.
- Venue
- Science
- Published
- 1976-04-23
- Volume
- 192
- Issue
- 4237
- Pages
- 382-385
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2093220261
- Cited by
- 252
- References
- 0
- FWCI
- 11.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hyperphagia and Obesity Following Serotonin Depletion by Intraventricular p-Chlorophenylalanine. https://app.cochat.ai/papers/10.1126/science.130678
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- Breisch, S. T., Zemlan, F. P., & Hoebel, B. G. (1976). Hyperphagia and Obesity Following Serotonin Depletion by Intraventricular p-Chlorophenylalanine. Science. https://doi.org/10.1126/science.130678
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
