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Cloning of a Second Type of Activin Receptor and Functional Characterization in Xenopus Embryos
Abstract
A complementary DNA coding for a second type of activin receptor (ActRIIB) has been cloned from Xenopus laevis that fulfills the structural criteria of a transmembrane protein serine kinase. Ectodermal explants from embryos injected with activin receptor RNA show increased sensitivity to activin, as measured by the induction of muscle actin RNA. In addition, injected embryos display developmental defects characterized by inappropriate formation of dorsal mesodermal tissue. These results demonstrate that this receptor is involved in signal transduction and are consistent with the proposed role of activin in the induction and patterning of mesoderm in Xenopus embryos.
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Cited by
Wieser, R., Wrana, J. L., & Massagué, J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07214.x · Cited by 699
Functional analysis of activins during mammalian development
Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., & Bradley, A. (1995) · Nature · doi:10.1038/374354a0 · Cited by 578
Activation of Signalling by the Activin Receptor Complex
Attisano, L., Wrana, J. L., Montalvo, E., & Massagué, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1066 · Cited by 316
Activins and Inhibins: Roles in Development, Physiology, and Disease
Namwanje, M., & Brown, C. W. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021881 · Cited by 294
A novel family of cell surface receptors with tyrosine kinase-like domain.
Masiakowski, P., & Carroll, R. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35733-8 · Cited by 272
Metadata
- Authors
- Mathews, L. S., Vale, W. W., & Kintner, C. R.
- Venue
- Science
- Published
- 1992-03-27
- Volume
- 255
- Issue
- 5052
- Pages
- 1702-1705
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2056468550
- Cited by
- 219
- References
- 0
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mathews, L. S., Vale, W. W., & Kintner, C. R. (1992). Cloning of a Second Type of Activin Receptor and Functional Characterization in Xenopus Embryos. Science. https://doi.org/10.1126/science.1313188
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
