Activins and Inhibins: Roles in Development, Physiology, and Disease
Open accessAbstract
Since their original discovery as regulators of follicle-stimulating hormone (FSH) secretion and erythropoiesis, the TGF-β family members activin and inhibin have been shown to participate in a variety of biological processes, from the earliest stages of embryonic development to highly specialized functions in terminally differentiated cells and tissues. Herein, we present the history, structures, signaling mechanisms, regulation, and biological processes in which activins and inhibins participate, including several recently discovered biological activities and functional antagonists. The potential therapeutic relevance of these advances is also discussed.
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Activins, inhibins, and ovarian produced steroid hormones (estradiol and progesterone) feedback to regulate secretion of gonadotrophins.
“Activins, inhibins, and ovarian produced steroid hormones (estradiol and progesterone) feedback to regulate the secretion of the gonadotrophins [6].”
From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [6]
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“Activins, inhibins, and ovarian produced steroid hormones (estradiol and progesterone) feedback to regulate the secretion of the gonadotrophins [6].”
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- Authors
- Namwanje, M., & Brown, C. W.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-06-21
- Volume
- 8
- Issue
- 7
- Pages
- a021881
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC4930927
- OpenAlex
- W2460662933
- Cited by
- 294
- References
- 19
- Citations by year
- 2026: 29 · 2025: 47 · 2024: 45 · 2023: 28 · 2022: 36 · 2021: 32 · 2020: 36 · 2019: 20 · 2018: 11 · 2017: 9 · 2016: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- activin, inhibin, TGF-beta superfamily, activin signaling, erythropoiesis, embryonic development, therapeutic target
- MeSH terms
- Animals, Female, Humans, Inhibins, Ligands, Protein Conformation, Signal Transduction, Activins
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