The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Cytochrome b 558 : the Flavin-Binding Component of the Phagocyte NADPH Oxidase
Abstract
The phagocyte respiratory burst oxidase is a flavin-adenine dinucleotide (FAD)-dependent dehydrogenase and an electron transferase that reduces molecular oxygen to superoxide anion, a precursor of microbicidal oxidants. Several proteins required for assembly of the oxidase have been characterized, but the identity of its flavin-binding component has been unclear. Oxidase activity was reconstituted in vitro with only the purified oxidase proteins p47 phox , p67 phox , Rac-related guanine nucleotide (GTP)-binding proteins, and membrane-bound cytochrome b 558 . The reconstituted oxidase required added FAD, and FAD binding was localized to cytochrome b 558 . Alignment of the amino acid sequence of the β subunit of cytochrome b 558 (gp91 phox ) with other flavoproteins revealed similarities to the nicotinamide adenine dinucleotide phosphate (reduced) (NADPH)-binding domains. Thus flavocytochrome b 558 is the only obligate electron transporting component of the NADPH oxidase.
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Cites
Royer-Pokora, B., Kunkel, L. M., Monaco, A. P., Goff, S. C., Newburger, P. E., Baehner, R. L., Cole, F. S., Curnutte, J. T., & Orkin, S. H. (1986) · Nature · doi:10.1038/322032a0 · Cited by 833
Cross, A. R., & Jones, O. T. G. (1986) · Biochemical Journal · doi:10.1042/bj2370111 · Cited by 551
Karplus, P. A., Daniels, M. J., & Herriott, J. R. (1991) · Science · doi:10.1126/science.1986412 · Cited by 536
Parkos, C. A., Allen, R. A., Cochrane, C. G., & Jesaitis, A. J. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113128 · Cited by 455
Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 c-src
Leto, T. L., Lomax, K. J., Volpp, B. D., Nunoi, H., Sechler, J. M. G., Nauseef, W. M., Clark, R. A., Gallin, J. I., & Malech, H. L. (1990) · Science · doi:10.1126/science.1692159 · Cited by 386
Self-citationSuperoxide-forming enzyme from human neutrophils: Evidence for a flavin requirement
Babior, B., & Kipnes, R. (1977) · Blood · doi:10.1182/blood.v50.3.517.517 · Cited by 174
Cited by
Cell transformation by the superoxide-generating oxidase Mox1
Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480
Pollock, J. D., Williams, D. A., Gifford, M. A. C., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., & Dinauer, M. C. (1995) · Nature Genetics · doi:10.1038/ng0295-202 · Cited by 921
Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5
Cheng, G., Cao, Z., Xu, X., Meir, E. G. V., & Lambeth, J. D. (2001) · Gene · doi:10.1016/s0378-1119(01)00449-8 · Cited by 819
Sumimoto, H. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06488.x · Cited by 721
A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes
Bánfi, B., Molnár, G., Maturana, A., Steger, K., Hegedûs, B., Demaurex, N., & Krause, K.-H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103034200 · Cited by 622
Metadata
- Authors
- Rotrosen, D., Yeung, C. L., Leto, T. L., Malech, H. L., & Kwong, C. H.
- Venue
- Science
- Published
- 1992-06-05
- Volume
- 256
- Issue
- 5062
- Pages
- 1459-1462
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2119518322
- Cited by
- 378
- References
- 6
- FWCI
- 19.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rotrosen, D., Yeung, C. L., Leto, T. L., Malech, H. L., & Kwong, C. H. (1992). Cytochrome b 558 : the Flavin-Binding Component of the Phagocyte NADPH Oxidase. Science. https://doi.org/10.1126/science.1318579
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
