The DOI matches its Crossref record.
Properties of the Major Component of a Peptic Digest of Rabbit Antibody
Abstract
The molecular weight of the active, major component isolated from a peptic digest of rabbit antibody was found to be 106,000. After treatment with a disulfide-splitting reagent, the molecular weight was 56,000, and the products migrated as a single peak in the ultracentrifuge. The univalent fragments thus formed can be partially recombined by passage through IR-120 cation-exchange resin at room temperature or by treatment with a difunctional organic mercurial. Some splitting of the pepsin-treated antibody molecule occurs on carboxymethylcellulose at p H 5.4.
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Cited by
Bispecific antibodies: a mechanistic review of the pipeline
Labrijn, A. F., Janmaat, M. L., Reichert, J. M., & Parren, P. W. H. I. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0028-1 · Cited by 1,303
Privalov, P. L. (1982) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60468-4 · Cited by 731
STUDIES ON STRUCTURAL UNITS OF THE γ-GLOBULINS
Edelman, G. M., & Poulik, M. D. (1961) · The Journal of Experimental Medicine · doi:10.1084/jem.113.5.861 · Cited by 461
Intravenous Administration of Human γ‐Globulin*
Barandun, S., Kistler, P., Jeunet, F., & Isliker, H. (1962) · Vox Sanguinis · doi:10.1111/j.1423-0410.1962.tb03240.x · Cited by 386
Recombination of a mixture of univalent antibody fragments of different specificity
Nisonoff, A., & Rivers, M. M. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90296-x · Cited by 277
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Metadata
- Authors
- Nisonoff, A., Wissler, F. C., & Lipman, L. N.
- Venue
- Science
- Published
- 1960-12-09
- Volume
- 132
- Issue
- 3441
- Pages
- 1770-1771
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980802782
- Cited by
- 245
- References
- 0
- FWCI
- 17.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nisonoff, A., Wissler, F. C., & Lipman, L. N. (1960). Properties of the Major Component of a Peptic Digest of Rabbit Antibody. Science. https://doi.org/10.1126/science.132.3441.1770
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