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The Role of GABA B Receptor Activation in Absence Seizures of Lethargic ( lh / lh ) Mice
Abstract
Lethargic ( lh / lh ) mice, which function as an animal model of absence seizures, have spontaneous seizures that have behavioral and electrographic features and anticonvulsant sensitivity similar to those of human absence seizures. Antagonists of the γ-aminobutyric acid B (GABA B ) receptor suppressed these seizures in lethargic mice, whereas agonists of GABA B receptors exacerbated them. Furthermore, GABA B receptor binding and synaptically evoked GABA B receptor-mediated inhibition of N -methyl-D-aspartate responses were selectively increased in lh / lh mice. Therefore, enhanced GABA B receptor-mediated synaptic responses may underlie absence seizures in lh / lh mice, and GABA B receptor antagonists hold promise as anticonvulsants for absence seizures.
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Cited by
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McCormick, D. A., & Bal, T. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.185 · Cited by 1,267
Bowery, N. G., Bettler, B., Froestl, W., Gallagher, J. P., Marshall, F., Raiteri, M., Bonner, T. I., & Enna, S. J. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.247 · Cited by 601
Sensory gating mechanisms of the thalamus
McCormick, D. A., & Bal, T. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90056-6 · Cited by 392
Barclay, J., Balaguero, N., Mione, M., Ackerman, S. L., Letts, V. A., Brodbeck, J., Canti, C., Meir, A., Page, K. M., Kusumi, K., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06095.2001 · Cited by 326
Interactions Between Membrane Conductances Underlying Thalamocortical Slow-Wave Oscillations
DESTEXHE, A., & SEJNOWSKI, T. J. (2003) · Physiological Reviews · doi:10.1152/physrev.00012.2003 · Cited by 241
Metadata
- Authors
- Hosford, D. A., Clark, S., Cao, Z., Wilson, W. A., Lin, F.-H., Morrisett, R. A., & Huin, A.
- Venue
- Science
- Published
- 1992-07-17
- Volume
- 257
- Issue
- 5068
- Pages
- 398-401
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2004361024
- Cited by
- 356
- References
- 0
- FWCI
- 22.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hosford, D. A., Clark, S., Cao, Z., Wilson, W. A., Lin, F.-H., Morrisett, R. A., & Huin, A. (1992). The Role of GABA B Receptor Activation in Absence Seizures of Lethargic ( lh / lh ) Mice. Science. https://doi.org/10.1126/science.1321503
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
