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Cited by 241Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchIon channel regulation and function

Interactions Between Membrane Conductances Underlying Thalamocortical Slow-Wave Oscillations

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DESTEXHE, A., SEJNOWSKI, T. J.·2003·Physiological Reviews
DOI 10.1152/physrev.00012.2003PMC PMC2927823
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Abstract

Destexhe, A., and T. J. Sejnowski. Interactions Between Membrane Conductances Underlying Thalamocortical Slow-Wave Oscillations. Physiol Rev 83: 1401-1453, 2003; 10.1152/physrev.00012.2003.—Neurons of the central nervous system display a broad spectrum of intrinsic electrophysiological properties that are absent in the traditional “integrate-and-fire” model. A network of neurons with these properties interacting through synaptic receptors with many time scales can produce complex patterns of activity that cannot be intuitively predicted. Computational methods, tightly linked to experimental data, provide insights into the dynamics of neural networks. We review this approach for the case of bursting neurons of the thalamus, with a focus on thalamic and thalamocortical slow-wave oscillations. At the single-cell level, intrinsic bursting or oscillations can be explained by interactions between calcium- and voltage-dependent channels. At the network level, the genesis of oscillations, their initiation, propagation, termination, and large-scale synchrony can be explained by interactions between neurons with a variety of intrinsic cellular properties through different types of synaptic receptors. These interactions can be altered by neuromodulators, which can dramatically shift the large-scale behavior of the network, and can also be disrupted in many ways, resulting in pathological patterns of activity, such as seizures. We suggest a coherent framework that accounts for a large body of experimental data at the ion-channel, single-cell, and network levels. This framework suggests physiological roles for the highly synchronized oscillations of slow-wave sleep.

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  • There is evidence that ODP critically depends on T-type calcium channel function, which also plays an essential role in generating spindles and slow oscillations during non-REM sleep.

    “Interestingly, there is evidence that ODP critically depends on the T-type calcium channel function ( 1224), which also plays an essential role in the generation of spindles and slow oscillations during non-REM sleep (282, 283).”

    From About Sleep's Role in Memory (2013) · cites this paper as [283]

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Authors
DESTEXHE, A., & SEJNOWSKI, T. J.
Affiliations
Unité de Neurosciences Intégratives et Computationnelles, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France; Howard Hughes Medical Institute and the Salk Institute; Department of Biology, University of California at San Diego, La Jolla, California
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2003-10
Volume
83
Issue
4
Pages
1401-1453
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00012.2003
PMC
PMC2927823
OpenAlex
W2135997508
Cited by
241
References
368
Citations by year
2026: 7 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 5 · 2019: 9 · 2018: 6 · 2017: 12 · 2016: 19 · 2015: 7 · 2014: 20 · 2013: 15 · 2012: 13
FWCI
0.91
Type
journal article
Language
en
Open access
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
thalamocortical oscillations, slow-wave sleep, membrane conductance, calcium channels, voltage-gated ion channels, synaptic receptors, neural network dynamics, neuronal synchronization, neuromodulation, seizures, neuron modeling
MeSH terms
Action Potentials, Animals, Biological Clocks, Cerebral Cortex, Electroencephalography, Humans, Neurons, Thalamus

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