The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors
Abstract
The rate and extent of the agonist-dependent phosphorylation of β 2 -adrenergic receptors and rhodopsin by β-adrenergic receptor kinase (βARK) are markedly enhanced on addition of G protein βγ subunits. With a model peptide substrate it was demonstrated that direct activation of the kinase could not account for this effect. G protein βγ subunits were shown to interact directly with the COOH-terminal region of βARK, and formation of this βARK-βγ complex resulted in receptor-facilitated membrane localization of the enzyme. The βγ subunits of transducin were less effective at both enhancing the rate of receptor phosphorylation and binding to the COOH-terminus of βARK, suggesting that the enzyme preferentially binds specific βγ complexes. The βγ-mediated membrane localization of βARK serves to intimately link receptor activation to βARK-mediated desensitization.
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Cites
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Cited by
Mitogenic signaling via G protein-coupled receptors
van BIESEN, T., LUTTRELL, L. M., HAWES, B. E., & LEFKOWITZ, R. J. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-6-698 · Cited by 361
Self-citationRhodopsin phosphorylation: 30 years later
Maeda, T. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(03)00017-x · Cited by 152
G-protein γ subunit GNG11 strongly regulates cellular senescence
Hossain, M. N., Sakemura, R., Fujii, M., & Ayusawa, D. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.112 · Cited by 57
Targeting G protein coupled receptor-related pathways as emerging molecular therapies
Ghanemi, A. (2015) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2013.07.007 · Cited by 53
Zhao, W.-L., Wang, D., Liu, C.-Y., & Zhao, X.-F. (2016) · Scientific Reports · doi:10.1038/srep29205 · Cited by 12
Metadata
- Authors
- Pitcher, J. A., Inglese, J., Higgins, J. B., Arriza, J. L., Casey, P. J., Kim, C., Benovic, J. L., Kwatra, M. M., Caron, M. G., & Lefkowitz, R. J.
- Venue
- Science
- Published
- 1992-08-28
- Volume
- 257
- Issue
- 5074
- Pages
- 1264-1267
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086617442
- Cited by
- 717
- References
- 2
- FWCI
- 19.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pitcher, J. A., Inglese, J., Higgins, J. B., Arriza, J. L., Casey, P. J., Kim, C., Benovic, J. L., Kwatra, M. M., Caron, M. G., & Lefkowitz, R. J. (1992). Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors. Science. https://doi.org/10.1126/science.1325672
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