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The cytosensor microphysiometer: biological applications of silicon technology
Abstract
A silicon-based device, dubbed a microphysiometer, can be used to detect and monitor the response of cells to a variety of chemical substances, especially ligands for specific plasma membrane receptors. The microphysiometer measures the rate of proton excretion from 10(4) to 10(6) cells. This article gives an overview of experiments currently being carried out with this instrument with emphasis on receptors with seven transmembrane helices and tyrosine kinase receptors. As a scientific instrument, the microphysiometer can be thought of as serving two distinct functions. In terms of detecting specific molecules, selected biological cells in this instrument serve as detectors and amplifiers. The microphysiometer can also investigate cell function and biochemistry. A major application of this instrument may prove to be screening for new receptor ligands. In this respect, the microphysiometer appears to offer significant advantages over other techniques.
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Cited by
Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000
Supported membranes on soft polymer cushions: fabrication, characterization and applications
Sackmann, E., & Tanaka, M. (2000) · Trends in Biotechnology · doi:10.1016/s0167-7799(99)01412-2 · Cited by 417
Comparison of the hysteresis of Ta2O5 and Si3N4 pH-sensing insulators
Bousse, L., Mostarshed, S., van der Schoot, B., & de Rooij, N. F. (1994) · Sensors and Actuators B: Chemical · doi:10.1016/0925-4005(94)87044-6 · Cited by 177
Torisawa, Y.-S., Shiku, H., Yasukawa, T., Nishizawa, M., & Matsue, T. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.05.028 · Cited by 124
Metadata
- Authors
- McConnell, H., Owicki, J., Parce, J., Miller, D., Baxter, G., Wada, H., & Pitchford, S.
- Venue
- Science
- Published
- 1992-09-25
- Volume
- 257
- Issue
- 5078
- Pages
- 1906-1912
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036213823
- Cited by
- 622
- References
- 0
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- McConnell, H., Owicki, J., Parce, J., Miller, D., Baxter, G., Wada, H., & Pitchford, S. (1992). The cytosensor microphysiometer: biological applications of silicon technology. Science. https://doi.org/10.1126/science.1329199
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