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Microdomains of High Calcium Concentration in a Presynaptic Terminal
Abstract
Increases in intracellular calcium concentration are required for the release of neurotransmitter from presynaptic terminals in all neurons. However, the mechanism by which calcium exerts its effect is not known. A low-sensitivity calcium-dependent photoprotein ( n -aequorin-J) was injected into the presynaptic terminal of the giant squid synapse to selectively detect high calcium concentration microdomains. During transmitter release, light emission occurred at specific points or quantum emission domains that remained in the same place during protracted stimulation. Intracellular calcium concentration microdomains on the order of 200 to 300 micromolar occur against the cytoplasmic surface of the plasmalemma during transmitter secretion, supporting the view that the synaptic vesicular fusion responsible for transmitter release is triggered by the activation of a low-affinity calcium-binding site at the active zone.
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Citations
Cited by
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Rizzuto, R., & Pozzan, T. (2006) · Physiological Reviews · doi:10.1152/physrev.00004.2005 · Cited by 1,206
Neher, E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80983-6 · Cited by 1,010
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Calcium Channel Regulation and Presynaptic Plasticity
Catterall, W. A., & Few, A. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.005 · Cited by 647
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction
Kaeser, P. S., Deng, L., Wang, Y., Dulubova, I., Liu, X., Rizo, J., & Südhof, T. C. (2011) · Cell · doi:10.1016/j.cell.2010.12.029 · Cited by 607
Metadata
- Authors
- Llinás, R., Sugimori, M., & Silver, R. B.
- Venue
- Science
- Published
- 1992-05
- Volume
- 256
- Issue
- 5057
- Pages
- 677-679
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2032562864
- Cited by
- 837
- References
- 0
- FWCI
- 27.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Llinás, R., Sugimori, M., & Silver, R. B. (1992). Microdomains of High Calcium Concentration in a Presynaptic Terminal. Science. https://doi.org/10.1126/science.1350109
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