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Programmed Death of T Cells in HIV-1 Infection
Abstract
In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4 + and CD8 + T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency.
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Citations
Cited by
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Programmed Cell Death Induced by Ceramide
Obeid, L. M., Linardic, C. M., Karolak, L. A., & Hannun, Y. A. (1993) · Science · doi:10.1126/science.8456305 · Cited by 1,794
Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S. A., Petit, P. X., Mignotte, B., & Kroemer, G. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.2.367 · Cited by 1,567
Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssière, J. L., Petit, P. X., & Kroemer, G. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.5.1661 · Cited by 1,166
Functionalized Fullerenes in Water. The First 10 Years of Their Chemistry, Biology, and Nanoscience
Nakamura, E., & Isobe, H. (2003) · Accounts of Chemical Research · doi:10.1021/ar030027y · Cited by 873
Metadata
- Authors
- Meyaard, L., Otto, S. A., Jonker, R. R., Mijnster, M. J., Keet, R. P. M., & Miedema, F.
- Venue
- Science
- Published
- 1992-07-10
- Volume
- 257
- Issue
- 5067
- Pages
- 217-219
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081200884
- Cited by
- 898
- References
- 0
- FWCI
- 28.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Programmed Death of T Cells in HIV-1 Infection. https://app.cochat.ai/papers/10.1126/science.1352911
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- Meyaard, L., Otto, S. A., Jonker, R. R., Mijnster, M. J., Keet, R. P. M., & Miedema, F. (1992). Programmed Death of T Cells in HIV-1 Infection. Science. https://doi.org/10.1126/science.1352911
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
