The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Nature and Development of Lactic Dehydrogenases: The two major types of this enzyme form molecular hybrids which change in makeup during development
Abstract
The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation,
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Citations
Cites
MULTIPLE FORMS OF ENZYMES: TISSUE, ONTOGENETIC, AND SPECIES SPECIFIC PATTERNS
Markert, C. L., & Møller, F. (1959) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.45.5.753 · Cited by 1,072
IN VITRO METHOD FOR TESTING THE TOXIN‐PRODUCING CAPACITY OF DIPHTHERIA BACTERIA
Ouchterlony, O. (1948) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/j.1699-0463.1948.tb00655.x · Cited by 866
Méthode immuno-électrophorétique d'analyse de mélanges de substances antigéniques
Grabar, P., & Williams, C. A. (1955) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(55)90320-6 · Cited by 639
Dissociation of lactate dehydrogenase into subunits with guanidine hydrochloride
Appella, E., & Markert, C. L. (1961) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(61)90123-1 · Cited by 451
Molecular Heterogeneity and Evolution of Enzymes
Kaplan, N. O., Ciotti, M. M., Bieber, R. E., & Hamolsky, M. W. (1960) · Science · doi:10.1126/science.131.3398.392 · Cited by 258
Self-citationThe Electrophoretically Distinct Forms of Mammalian Lactic Dehydrogenase
Plagemann, P. G. W., Gregory, K. F., & Wröblewski, F. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64613-7 · Cited by 249
Cited by
Hypoxia and Metabolic Adaptation of Cancer Cells
Eales, K. L., Hollinshead, K. E. R., & Tennant, D. A. (2016) · Oncogenesis · doi:10.1038/oncsis.2015.50 · Cited by 724
Zheng, X., Boyer, L., Jin, M., Mertens, J., Kim, Y., Ma, L., Ma, L., Hamm, M., Gage, F. H., & Hunter, T. (2016) · eLife · doi:10.7554/elife.13374 · Cited by 671
“The A4 isozyme kinetically favors the conversion from pyruvate to lactate, while the B4 isozyme prefer converting lactate to pyruvate (Cahn et al., 1962).”
BackgroundMetabolic Differentiation of Distinct Muscle Types at the Level of Enzymatic Organization
Bass, A., Brdiczka, D., Eyer, P., Hofer, S., & Pette, D. (1969) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1969.tb00674.x · Cited by 668
Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
Bittar, P. G., Charnay, Y., Pellerin, L., Bouras, C., & Magistretti, P. J. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199611000-00001 · Cited by 423
Understanding metabolic regulation and its influence on cell physiology
Metallo, C. M., & Vander Heiden, M. G. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.018 · Cited by 367
Metadata
- Authors
- Cahn, R. D., Zwilling, E., Kaplan, N. O., & Levine, L.
- Venue
- Science
- Published
- 1962-06-15
- Volume
- 136
- Issue
- 3520
- Pages
- 962-969
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072212474
- Cited by
- 940
- References
- 6
- FWCI
- 77.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Nature and Development of Lactic Dehydrogenases: The two major types of this enzyme form molecular hybrids which change in makeup during development. https://app.cochat.ai/papers/10.1126/science.136.3520.962
- The paper
- Cahn, R. D., Zwilling, E., Kaplan, N. O., & Levine, L. (1962). Nature and Development of Lactic Dehydrogenases: The two major types of this enzyme form molecular hybrids which change in makeup during development. Science. https://doi.org/10.1126/science.136.3520.962
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
