Understanding metabolic regulation and its influence on cell physiology

Metallo, Christian M.; Vander Heiden, Matthew G.

doi:10.1016/j.molcel.2013.01.018

Cited by 367Microbial Metabolic Engineering and BioproductionGene Regulatory Network AnalysisBioinformatics and Genomic Networks

Understanding metabolic regulation and its influence on cell physiology

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Metallo, Christian M., Vander Heiden, Matthew G.·2013·Molecular Cell

DOI 10.1016/j.molcel.2013.01.018PMC PMC3569837

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Abstract

Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last century, our knowledge of metabolic pathway architecture and the genomic landscape of disease has increased exponentially. Combined with these insights, advances in analytical methods for quantifying metabolites and systems approaches to analyze these data now provide powerful tools to study metabolic regulation. Here we review the diverse mechanisms cells use to adapt metabolism to specific physiological states and discuss how metabolic flux analyses can be applied to identify important regulatory nodes to understand normal and pathological cell physiology.

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Succinate inhibits HIF-1α signaling through inhibition of PHD2 but can also impact the activity of numerous α-ketoglutarate-dependent dioxygenases.
“Succinate inhibits HIF-1␣ signaling through inhibition of PHD2 but can also impact the activity of numerous ␣-ketoglutarate-dependent dioxygenases (42,43).”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [43]

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Metabolomics: beyond biomarkers and towards mechanisms
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AMPK governs lineage specification through Tfeb-dependent regulation of lysosomesPreprint
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Induction of Oxidative Stress Through Inhibition of Thioredoxin Reductase 1 Is an Effective Therapeutic Approach for Hepatocellular Carcinoma
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Metabolic consequences of oncogenic IDH mutations
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LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2
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Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma
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Redox control of glutamine utilization in cancer
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WNT Signaling: an Emerging Mediator of Cancer Cell Metabolism?
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Control of endothelial quiescence by FOXO-regulated metabolites
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Cells grown in three-dimensional spheroids mirror in vivo metabolic response of epithelial cells
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Metabolic requirements for cancer cell proliferation
Keibler, M. A., Wasylenko, T. M., Kelleher, J. K., Iliopoulos, O., Heiden, M. G. V., & Stephanopoulos, G. N. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0156-6 · Cited by 135 · see citing works
Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function
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Cellular Respiration: The Nexus of Stress, Condition, and Ornamentation
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Organ-Specific Cancer Metabolism and Its Potential for Therapy
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N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes
Aichler, M., Borgmann, D. M., Krumsiek, J., Buck, A., MacDonald, P. E., Fox, J. E. M., Lyon, J. G., Light, P. E., Keipert, S., Jastroch, M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.012 · Cited by 115 · see citing works
Metabolic acclimation of anammox consortia to decreased temperature
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How metabolites modulate metabolic flux
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Regulatory mechanisms of one-carbon metabolism enzymes
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PIP 2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity
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A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels
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Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo
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Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets
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Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?
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Authors: Metallo, C. M., & Vander Heiden, M. G.
Affiliations: University of California San Diego (US)
Corresponding author: Metallo, Christian M.
ORCID: Metallo, Christian M.
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2013-02
Volume: 49
Issue: 3
Pages: 388-398
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2013.01.018
PMC: PMC3569837
OpenAlex: W2024399152
Cited by: 367
References: 100
Citations by year: 2026: 26 · 2025: 39 · 2024: 36 · 2023: 24 · 2022: 25 · 2021: 37 · 2020: 35 · 2019: 31 · 2018: 25 · 2017: 16 · 2016: 19 · 2015: 24 · 2014: 23 · 2013: 6
FWCI: 2.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Funders: American Cancer Society (70-002)
Damon Runyon Cancer Research Foundation
Richard and Susan Smith Family Foundation
Burroughs Wellcome Fund
National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords: metabolic regulation, cell physiology, metabolic flux analysis, metabolic adaptation, metabolite quantification, metabolic disorders
MeSH terms: Animals, Cell Physiological Phenomena, Cells, Glycolysis, Humans, Models, Biological, Metabolic Networks and Pathways

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Understanding metabolic regulation and its influence on cell physiology

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