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Regulation of Adenylyl Cyclase from Paramecium by an Intrinsic Potassium Conductance
Abstract
Hyperpolarization of the cell membrane of Paramecium stimulates adenosine 3′,5′-monophosphate (cAMP) formation. Manipulations of the K + resting conductance of the ciliate by adaptation in different buffers affected excitability of the cAMP generating system. Blockade of K + channels inhibited hyperpolarization-stimulated cAMP formation. A mutant of Paramecium that is unable to control its K + resting conductance had a defect in cAMP formation. Purified adenylyl cyclase, when incorporated into an artificial lipid bilayer membrane, revealed properties of a voltage-independent K + channel. This indicates that the adenylyl cyclase of Paramecium has a secondary function as carrier of the K + resting conductance. A hyperpolarization-activated K + efflux appears to directly regulate adenylyl cyclase activity in vivo.
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Cited by
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Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
Complexity and Diversity of Mammalian Adenylyl Cyclases
Sunahara, R. K., Dessauer, C. W., & Gilman, A. G. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.002333 · Cited by 874
Mammalian Membrane-bound Adenylyl Cyclases
Taussig, R., & Gilman, A. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.1.1 · Cited by 721
Organization and Ca2+Regulation of Adenylyl Cyclases in cAMP Microdomains
Willoughby, D., & Cooper, D. M. F. (2007) · Physiological Reviews · doi:10.1152/physrev.00049.2006 · Cited by 451
Regulation and organization of adenylyl cyclases and cAMP
COOPER, D. M. F. (2003) · Biochemical Journal · doi:10.1042/bj20031061 · Cited by 356
Metadata
- Authors
- Schultz, J. E., Klumpp, S., Benz, R., Schürhoff-Goeters, W. J. C., & Schmid, A.
- Venue
- Science
- Published
- 1992-01-31
- Volume
- 255
- Issue
- 5044
- Pages
- 600-603
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016400146
- Cited by
- 159
- References
- 0
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Regulation of Adenylyl Cyclase from Paramecium by an Intrinsic Potassium Conductance. https://app.cochat.ai/papers/10.1126/science.1371017
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- Schultz, J. E., Klumpp, S., Benz, R., Schürhoff-Goeters, W. J. C., & Schmid, A. (1992). Regulation of Adenylyl Cyclase from Paramecium by an Intrinsic Potassium Conductance. Science. https://doi.org/10.1126/science.1371017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
