The DOI matches its Crossref record.
CD19: Lowering the Threshold for Antigen Receptor Stimulation of B Lymphocytes
Abstract
Lymphocytes must proliferate and differentiate in response to low concentrations of a vast array of antigens. The requirements of broad specificity and sensitivity conflict because the former is met by low-affinity antigen receptors, which precludes achieving the latter with high-affinity receptors. Coligation of the membrane protein CD19 with the antigen receptor of B lymphocytes decreased the threshold for antigen receptor-dependent stimulation by two orders of magnitude. B lymphocytes proliferated when approximately 100 antigen receptors per cell, 0.03 percent of the total, were coligated with CD19. The B cell resolves its dilemma by having an accessory protein that enables activation when few antigen receptors are occupied.
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Citations
Cited by
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Carroll, M. C. (2004) · Nature Immunology · doi:10.1038/ni1113 · Cited by 1,035
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Singh, A. K., & McGuirk, J. P. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30823-x · Cited by 303
Complement receptors and their role in leukocyte recruitment and phagocytosis
Vandendriessche, S., Cambier, S., Proost, P., & Marques, P. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.624025 · Cited by 178
Defective B cell receptor‐mediated responses in mice lacking the Ets protein, Spi‐B
Su, G. H., Chen, H., Muthusamy, N., Garrett‐Sinha, L. A., Baunoch, D., Tenen, D. G., & Simon, M. C. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.7118 · Cited by 182
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Metadata
- Authors
- Carter, R. H., & Fearon, D. T.
- Venue
- Science
- Published
- 1992-04-03
- Volume
- 256
- Issue
- 5053
- Pages
- 105-107
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2078225503
- Cited by
- 674
- References
- 0
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
